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Appropriateness Criteria

Variant 1: Adult female, 40 years of age or older. Palpable breast mass. Initial imaging.
Procedure Appropriateness Category SOE Adult RRL Peds RRL Rating Median Final Tabulations
1 2 3 4 5 6 7 8 9
Digital breast tomosynthesis diagnostic Usually appropriate Strong ☢☢ 0.1-1mSv 9 9 0 0 0 0 0 0 0 1 16
References Study Quality
17 (22593120) 2
16 (26133221) 2
15 (29174225) 3
14 (24475859) 3
13 (23255766) 3
12 (21998048) 2
11 (23345348) 2
Mammography diagnostic Usually appropriate Limited ☢☢ 0.1-1mSv 9 9 0 0 0 0 0 0 2 2 13
References Study Quality
22 (32023120) 3
21 (27081707) 3
20 (12636326) 3
19 (17929256) 4
18 (17350262) 3
US breast May be appropriate Limited O 0 mSv O 0 mSv [ped] 5 5 0 0 0 2 9 2 1 3 0
References Study Quality
26 (11348373) 3
21 (27081707) 3
9 (12418762) 3
8 (12355002) 3
7 (11274555) 3
2 (25341156) 4
Digital breast tomosynthesis screening Usually not appropriate Expert Consensus ☢☢ 0.1-1mSv 1 1 13 1 2 0 0 1 0 0 0
Mammography screening Usually not appropriate Expert Consensus ☢☢ 0.1-1mSv 1 1 13 1 2 0 0 1 0 0 0
Image-guided core biopsy breast Usually not appropriate Expert Consensus Varies Varies 1 1 14 0 1 0 2 0 0 0 0
Image-guided fine needle aspiration breast Usually not appropriate Expert Consensus Varies Varies 1 1 15 0 0 0 2 0 0 0 0
MRI breast without and with IV contrast Usually not appropriate Limited O 0 mSv O 0 mSv [ped] 1 1 11 1 3 1 0 0 1 0 0
References Study Quality
23 (28754486) 3
2 (25341156) 4
24 (23046046) 3
25 (21477168) 3
MRI breast without IV contrast Usually not appropriate Limited O 0 mSv O 0 mSv [ped] 1 1 14 1 2 0 0 0 0 0 0
References Study Quality
2 (25341156) 4
25 (21477168) 3
24 (23046046) 3
23 (28754486) 3
FDG-PET breast dedicated Usually not appropriate Limited ☢☢☢ 1-10 mSv 1 1 14 2 1 0 0 0 0 0 0
References Study Quality
2 (25341156) 4
Sestamibi MBI Usually not appropriate Expert Consensus ☢☢☢ 1-10 mSv 1 1 16 0 1 0 0 0 0 0 0
Variant 2: Adult female, 40 years of age or older. Palpable breast mass. Mammography findings are suspicious or highly suggestive of malignancy (BI-RADS 4 or 5). Next imaging study.
Procedure Appropriateness Category SOE Adult RRL Peds RRL Rating Median Final Tabulations
1 2 3 4 5 6 7 8 9
US breast Usually appropriate Limited O 0 mSv O 0 mSv [ped] 9 9 0 0 0 0 0 0 1 2 14
References Study Quality
35 (-3098655) 4
34 (12034957) 3
33 (16915997) 4
Image-guided core biopsy breast Usually not appropriate Limited Varies Varies 1 1 13 1 2 0 0 0 0 0 1
References Study Quality
27 (17924407) 3
30 (-3098656) 4
29 (23252555) 4
28 (25386875) 3
Image-guided fine needle aspiration breast Usually not appropriate Limited Varies Varies 1 1 14 3 0 0 0 0 0 0 0
References Study Quality
31 (27160231) 4
27 (17924407) 3
MRI breast without and with IV contrast Usually not appropriate Limited O 0 mSv O 0 mSv [ped] 1 1 10 2 3 0 1 0 1 0 0
References Study Quality
2 (25341156) 4
32 (-3098654) 4
25 (21477168) 3
24 (23046046) 3
23 (28754486) 3
MRI breast without IV contrast Usually not appropriate Limited O 0 mSv O 0 mSv [ped] 1 1 13 0 4 0 0 0 0 0 0
References Study Quality
2 (25341156) 4
32 (-3098654) 4
25 (21477168) 3
24 (23046046) 3
23 (28754486) 3
FDG-PET breast dedicated Usually not appropriate Limited ☢☢☢ 1-10 mSv 1 1 13 1 2 0 1 0 0 0 0
References Study Quality
2 (25341156) 4
Sestamibi MBI Usually not appropriate Expert Consensus ☢☢☢ 1-10 mSv 1 1 14 2 1 0 0 0 0 0 0
Variant 3: Adult female, 40 years of age or older. Palpable breast mass. Diagnostic mammography, DBT, and US findings are probably benign (BI-RADS 3). Next imaging study.
Procedure Appropriateness Category SOE Adult RRL Peds RRL Rating Median Final Tabulations
1 2 3 4 5 6 7 8 9
Image-guided core biopsy breast Usually not appropriate Limited Varies Varies 3 3 2 2 7 0 5 1 0 0 0
References Study Quality
37 (-3098658) 4
27 (17924407) 3
30 (-3098656) 4
36 (4228709) 4
Image-guided fine needle aspiration breast Usually not appropriate Limited Varies Varies 2 2 7 2 5 0 2 1 0 0 0
References Study Quality
37 (-3098658) 4
31 (27160231) 4
27 (17924407) 3
30 (-3098656) 4
36 (4228709) 4
MRI breast without and with IV contrast Usually not appropriate Limited O 0 mSv O 0 mSv [ped] 1 1 11 2 1 1 1 1 0 0 0
References Study Quality
23 (28754486) 3
2 (25341156) 4
24 (23046046) 3
25 (21477168) 3
MRI breast without IV contrast Usually not appropriate Limited O 0 mSv O 0 mSv [ped] 1 1 15 1 1 0 0 0 0 0 0
References Study Quality
2 (25341156) 4
25 (21477168) 3
24 (23046046) 3
23 (28754486) 3
FDG-PET breast dedicated Usually not appropriate Limited ☢☢☢ 1-10 mSv 1 1 16 1 0 0 0 0 0 0 0
References Study Quality
2 (25341156) 4
Sestamibi MBI Usually not appropriate Expert Consensus ☢☢☢ 1-10 mSv 1 1 14 1 2 0 0 0 0 0 0
Variant 4: Adult female, 40 years of age or older. Palpable breast mass. Mammography findings are benign (BI-RADS 2) at the site of palpable mass. Next imaging study.
Procedure Appropriateness Category SOE Adult RRL Peds RRL Rating Median Final Tabulations
1 2 3 4 5 6 7 8 9
US breast May be appropriate Limited O 0 mSv O 0 mSv [ped] 5 5 3 1 3 0 10 0 0 0 0
References Study Quality
8 (12355002) 3
9 (12418762) 3
33 (16915997) 4
38 (22119297) 3
Image-guided core biopsy breast Usually not appropriate Expert Consensus Varies Varies 1 1 16 1 0 0 0 0 0 0 0
Image-guided fine needle aspiration breast Usually not appropriate Expert Consensus Varies Varies 1 1 15 2 0 0 0 0 0 0 0
MRI breast without and with IV contrast Usually not appropriate Expert Consensus O 0 mSv O 0 mSv [ped] 1 1 16 0 0 0 1 0 0 0 0
MRI breast without IV contrast Usually not appropriate Expert Consensus O 0 mSv O 0 mSv [ped] 1 1 17 0 0 0 0 0 0 0 0
FDG-PET breast dedicated Usually not appropriate Limited ☢☢☢ 1-10 mSv 1 1 16 0 1 0 0 0 0 0 0
References Study Quality
2 (25341156) 4
Sestamibi MBI Usually not appropriate Expert Consensus ☢☢☢ 1-10 mSv 1 1 17 0 0 0 0 0 0 0 0
Variant 5: Adult female, 40 years of age or older. Palpable breast mass. Mammography findings are negative (BI-RADS 1). Next imaging study.
Procedure Appropriateness Category SOE Adult RRL Peds RRL Rating Median Final Tabulations
1 2 3 4 5 6 7 8 9
US breast Usually appropriate Limited O 0 mSv O 0 mSv [ped] 9 9 0 0 1 1 1 0 2 3 9
References Study Quality
2 (25341156) 4
8 (12355002) 3
9 (12418762) 3
26 (11348373) 3
22 (32023120) 3
20 (12636326) 3
19 (17929256) 4
18 (17350262) 3
39 (19933671) 3
38 (22119297) 3
40 (23096195) 3
Image-guided core biopsy breast Usually not appropriate Limited Varies Varies 1 1 16 0 0 0 1 0 0 0 0
References Study Quality
38 (22119297) 3
Image-guided fine needle aspiration breast Usually not appropriate Limited Varies Varies 1 1 17 0 0 0 0 0 0 0 0
References Study Quality
38 (22119297) 3
MRI breast without and with IV contrast Usually not appropriate Limited O 0 mSv O 0 mSv [ped] 1 1 12 1 1 0 3 0 0 0 0
References Study Quality
23 (28754486) 3
2 (25341156) 4
8 (12355002) 3
9 (12418762) 3
19 (17929256) 4
24 (23046046) 3
25 (21477168) 3
MRI breast without IV contrast Usually not appropriate Limited O 0 mSv O 0 mSv [ped] 1 1 16 0 1 0 0 0 0 0 0
References Study Quality
25 (21477168) 3
24 (23046046) 3
23 (28754486) 3
19 (17929256) 4
9 (12418762) 3
8 (12355002) 3
2 (25341156) 4
FDG-PET breast dedicated Usually not appropriate Limited ☢☢☢ 1-10 mSv 1 1 17 0 0 0 0 0 0 0 0
References Study Quality
2 (25341156) 4
Sestamibi MBI Usually not appropriate Expert Consensus ☢☢☢ 1-10 mSv 1 1 17 0 0 0 0 0 0 0 0
Variant 6: Adult female, younger than 30 years of age. Palpable breast mass. Initial imaging.
Procedure Appropriateness Category SOE Adult RRL Peds RRL Rating Median Final Tabulations
1 2 3 4 5 6 7 8 9
US breast Usually appropriate Limited O 0 mSv O 0 mSv [ped] 9 9 0 0 0 0 1 0 0 2 14
References Study Quality
42 (1732936) 4
41 (2267387) 3
33 (16915997) 4
43 (2664867) 3
44 (3763885) 4
47 (26742998) 4
Digital breast tomosynthesis diagnostic Usually not appropriate Limited ☢☢ 0.1-1mSv 1 1 14 0 2 1 0 0 0 0 0
References Study Quality
44 (3763885) 4
43 (2664867) 3
42 (1732936) 4
41 (2267387) 3
45 (22358028) 4
46 (12558355) 3
Digital breast tomosynthesis screening Usually not appropriate Expert Consensus ☢☢ 0.1-1mSv 1 1 16 0 0 0 0 0 0 1 0
Mammography diagnostic Usually not appropriate Limited ☢☢ 0.1-1mSv 1 1 13 0 2 1 0 0 0 1 0
References Study Quality
44 (3763885) 4
43 (2664867) 3
42 (1732936) 4
41 (2267387) 3
45 (22358028) 4
46 (12558355) 3
Mammography screening Usually not appropriate Expert Consensus ☢☢ 0.1-1mSv 1 1 16 0 0 0 0 0 0 1 0
Image-guided core biopsy breast Usually not appropriate Expert Consensus Varies Varies 1 1 15 0 0 0 1 0 1 0 0
Image-guided fine needle aspiration breast Usually not appropriate Expert Consensus Varies Varies 1 1 15 0 0 0 2 0 0 0 0
MRI breast without and with IV contrast Usually not appropriate Limited O 0 mSv O 0 mSv [ped] 1 1 13 0 2 1 0 0 1 0 0
References Study Quality
2 (25341156) 4
25 (21477168) 3
24 (23046046) 3
23 (28754486) 3
MRI breast without IV contrast Usually not appropriate Limited O 0 mSv O 0 mSv [ped] 1 1 15 0 1 1 0 0 0 0 0
References Study Quality
2 (25341156) 4
25 (21477168) 3
24 (23046046) 3
23 (28754486) 3
FDG-PET breast dedicated Usually not appropriate Limited ☢☢☢ 1-10 mSv 1 1 16 1 0 0 0 0 0 0 0
References Study Quality
2 (25341156) 4
Sestamibi MBI Usually not appropriate Expert Consensus ☢☢☢ 1-10 mSv 1 1 16 0 1 0 0 0 0 0 0
Variant 7: Adult female, younger than 30 years of age. Palpable breast mass. US findings are suspicious or highly suggestive of malignancy (BI-RADS 4 or 5). Next imaging study.
Procedure Appropriateness Category SOE Adult RRL Peds RRL Rating Median Final Tabulations
1 2 3 4 5 6 7 8 9
Digital breast tomosynthesis diagnostic Usually appropriate Strong ☢☢ 0.1-1mSv 8 8 0 0 0 0 2 2 4 1 8
References Study Quality
48 (26499000) 2
49 (24484063) 1
Mammography diagnostic Usually appropriate Limited ☢☢ 0.1-1mSv 7 7 0 0 1 0 2 2 4 2 6
References Study Quality
41 (2267387) 3
Image-guided core biopsy breast Usually appropriate Limited Varies Varies 9 9 1 0 1 0 2 0 1 3 9
References Study Quality
50 (21135519) 3
27 (17924407) 3
51 (22180235) 3
Image-guided fine needle aspiration breast May be appropriate (Disagreement) Expert Opinion Varies Varies 5 5 6 1 1 4 3 0 2 0 0
References Study Quality
50 (21135519) 3
27 (17924407) 3
51 (22180235) 3
Digital breast tomosynthesis screening Usually not appropriate Expert Consensus ☢☢ 0.1-1mSv 1 1 16 0 0 1 0 0 0 0 0
Mammography screening Usually not appropriate Expert Consensus ☢☢ 0.1-1mSv 1 1 16 0 0 1 0 0 0 0 0
MRI breast without and with IV contrast Usually not appropriate Limited O 0 mSv O 0 mSv [ped] 1 1 13 0 1 2 0 0 1 0 0
References Study Quality
2 (25341156) 4
25 (21477168) 3
24 (23046046) 3
23 (28754486) 3
MRI breast without IV contrast Usually not appropriate Limited O 0 mSv O 0 mSv [ped] 1 1 15 0 1 1 0 0 0 0 0
References Study Quality
2 (25341156) 4
25 (21477168) 3
24 (23046046) 3
23 (28754486) 3
FDG-PET breast dedicated Usually not appropriate Limited ☢☢☢ 1-10 mSv 1 1 16 0 1 0 0 0 0 0 0
References Study Quality
2 (25341156) 4
Sestamibi MBI Usually not appropriate Expert Consensus ☢☢☢ 1-10 mSv 1 1 16 0 1 0 0 0 0 0 0
Variant 8: Adult female, younger than 30 years of age. Palpable breast mass. US findings probably benign (BI-RADS 3). Next imaging study.
Procedure Appropriateness Category SOE Adult RRL Peds RRL Rating Median Final Tabulations
1 2 3 4 5 6 7 8 9
Digital breast tomosynthesis diagnostic Usually not appropriate Expert Consensus ☢☢ 0.1-1mSv 1 1 16 0 1 0 0 0 0 0 0
Digital breast tomosynthesis screening Usually not appropriate Expert Consensus ☢☢ 0.1-1mSv 1 1 16 0 1 0 0 0 0 0 0
Mammography diagnostic Usually not appropriate Expert Consensus ☢☢ 0.1-1mSv 1 1 16 0 1 0 0 0 0 0 0
Mammography screening Usually not appropriate Expert Consensus ☢☢ 0.1-1mSv 1 1 17 0 0 0 0 0 0 0 0
Image-guided core biopsy breast Usually not appropriate Limited Varies Varies 1 1 12 0 3 2 0 0 0 0 0
References Study Quality
30 (-3098656) 4
Image-guided fine needle aspiration breast Usually not appropriate Limited Varies Varies 1 1 13 1 2 1 0 0 0 0 0
References Study Quality
27 (17924407) 3
30 (-3098656) 4
MRI breast without and with IV contrast Usually not appropriate Limited O 0 mSv O 0 mSv [ped] 1 1 14 1 1 0 1 0 0 0 0
References Study Quality
2 (25341156) 4
25 (21477168) 3
24 (23046046) 3
23 (28754486) 3
MRI breast without IV contrast Usually not appropriate Limited O 0 mSv O 0 mSv [ped] 1 1 16 0 1 0 0 0 0 0 0
References Study Quality
2 (25341156) 4
25 (21477168) 3
24 (23046046) 3
23 (28754486) 3
FDG-PET breast dedicated Usually not appropriate Limited ☢☢☢ 1-10 mSv 1 1 17 0 0 0 0 0 0 0 0
References Study Quality
2 (25341156) 4
Sestamibi MBI Usually not appropriate Expert Consensus ☢☢☢ 1-10 mSv 1 1 17 0 0 0 0 0 0 0 0
Variant 9: Adult female, younger than 30 years of age. Palpable breast mass. US findings benign (BI-RADS 2). Next imaging study.
Procedure Appropriateness Category SOE Adult RRL Peds RRL Rating Median Final Tabulations
1 2 3 4 5 6 7 8 9
Digital breast tomosynthesis diagnostic Usually not appropriate Expert Consensus ☢☢ 0.1-1mSv 1 1 13 2 0 1 0 1 0 0 0
Digital breast tomosynthesis screening Usually not appropriate Expert Consensus ☢☢ 0.1-1mSv 1 1 16 0 0 0 1 0 0 0 0
Mammography diagnostic Usually not appropriate Expert Consensus ☢☢ 0.1-1mSv 1 1 13 2 0 1 0 1 0 0 0
Mammography screening Usually not appropriate Expert Consensus ☢☢ 0.1-1mSv 1 1 16 0 0 0 1 0 0 0 0
Image-guided core biopsy breast Usually not appropriate Limited Varies Varies 1 1 14 2 0 0 1 0 0 0 0
References Study Quality
52 (26274736) 3
Image-guided fine needle aspiration breast Usually not appropriate Expert Consensus Varies Varies 1 1 13 2 0 0 1 0 1 0 0
MRI breast without and with IV contrast Usually not appropriate Limited O 0 mSv O 0 mSv [ped] 1 1 15 1 0 0 0 0 0 1 0
References Study Quality
23 (28754486) 3
2 (25341156) 4
25 (21477168) 3
24 (23046046) 3
MRI breast without IV contrast Usually not appropriate Limited O 0 mSv O 0 mSv [ped] 1 1 15 1 1 0 0 0 0 0 0
References Study Quality
2 (25341156) 4
25 (21477168) 3
24 (23046046) 3
23 (28754486) 3
FDG-PET breast dedicated Usually not appropriate Limited ☢☢☢ 1-10 mSv 1 1 17 0 0 0 0 0 0 0 0
References Study Quality
2 (25341156) 4
Sestamibi MBI Usually not appropriate Expert Consensus ☢☢☢ 1-10 mSv 1 1 16 0 1 0 0 0 0 0 0
Variant 10: Adult female, younger than 30 years of age. Palpable breast mass. US findings negative (BI-RADS 1). Next imaging study.
Procedure Appropriateness Category SOE Adult RRL Peds RRL Rating Median Final Tabulations
1 2 3 4 5 6 7 8 9
Digital breast tomosynthesis diagnostic Usually not appropriate Limited ☢☢ 0.1-1mSv 1 1 9 1 2 3 1 0 0 1 0
References Study Quality
41 (2267387) 3
Digital breast tomosynthesis screening Usually not appropriate Expert Consensus ☢☢ 0.1-1mSv 1 1 16 0 0 0 1 0 0 0 0
Mammography diagnostic Usually not appropriate Limited ☢☢ 0.1-1mSv 1 1 9 1 2 3 1 0 0 1 0
References Study Quality
41 (2267387) 3
Mammography screening Usually not appropriate Expert Consensus ☢☢ 0.1-1mSv 1 1 16 0 0 0 1 0 0 0 0
Image-guided core biopsy breast Usually not appropriate Expert Consensus Varies Varies 1 1 16 0 0 0 1 0 0 0 0
Image-guided fine needle aspiration breast Usually not appropriate Expert Consensus Varies Varies 1 1 16 0 0 0 1 0 0 0 0
MRI breast without and with IV contrast Usually not appropriate Limited O 0 mSv O 0 mSv [ped] 1 1 12 2 2 0 0 0 0 1 0
References Study Quality
23 (28754486) 3
2 (25341156) 4
24 (23046046) 3
25 (21477168) 3
MRI breast without IV contrast Usually not appropriate Limited O 0 mSv O 0 mSv [ped] 1 1 15 1 1 0 0 0 0 0 0
References Study Quality
2 (25341156) 4
25 (21477168) 3
24 (23046046) 3
23 (28754486) 3
FDG-PET breast dedicated Usually not appropriate Limited ☢☢☢ 1-10 mSv 1 1 17 0 0 0 0 0 0 0 0
References Study Quality
2 (25341156) 4
Sestamibi MBI Usually not appropriate Expert Consensus ☢☢☢ 1-10 mSv 1 1 16 0 1 0 0 0 0 0 0
Variant 11: Adult female, 30 to 39 years of age. Palpable breast mass. Initial imaging.
Procedure Appropriateness Category SOE Adult RRL Peds RRL Rating Median Final Tabulations
1 2 3 4 5 6 7 8 9
US breast Usually appropriate Limited O 0 mSv O 0 mSv [ped] 8 8 0 0 0 0 3 0 3 3 8
References Study Quality
40 (23096195) 3
41 (2267387) 3
43 (2664867) 3
53 (17690501) 4
Digital breast tomosynthesis diagnostic Usually appropriate Strong ☢☢ 0.1-1mSv 9 9 0 0 0 0 1 1 3 3 9
References Study Quality
13 (23255766) 3
15 (29174225) 3
16 (26133221) 2
17 (22593120) 2
22 (32023120) 3
53 (17690501) 4
54 (28777649) 3
Mammography diagnostic Usually appropriate Limited ☢☢ 0.1-1mSv 8 8 0 0 0 0 1 1 3 4 8
References Study Quality
22 (32023120) 3
53 (17690501) 4
54 (28777649) 3
40 (23096195) 3
Digital breast tomosynthesis screening Usually not appropriate Expert Consensus ☢☢ 0.1-1mSv 1 1 16 0 0 0 1 0 0 0 0
Mammography screening Usually not appropriate Expert Consensus ☢☢ 0.1-1mSv 1 1 16 0 0 0 1 0 0 0 0
Image-guided core biopsy breast Usually not appropriate Expert Consensus Varies Varies 1 1 14 1 0 0 0 0 1 0 1
Image-guided fine needle aspiration breast Usually not appropriate Expert Consensus Varies Varies 1 1 14 1 0 0 1 1 0 0 0
MRI breast without and with IV contrast Usually not appropriate Limited O 0 mSv O 0 mSv [ped] 1 1 13 1 1 1 0 0 1 0 0
References Study Quality
2 (25341156) 4
25 (21477168) 3
24 (23046046) 3
23 (28754486) 3
MRI breast without IV contrast Usually not appropriate Limited O 0 mSv O 0 mSv [ped] 1 1 15 0 1 1 0 0 0 0 0
References Study Quality
2 (25341156) 4
25 (21477168) 3
24 (23046046) 3
23 (28754486) 3
FDG-PET breast dedicated Usually not appropriate Limited ☢☢☢ 1-10 mSv 1 1 16 0 0 1 0 0 0 0 0
References Study Quality
2 (25341156) 4
Sestamibi MBI Usually not appropriate Expert Consensus ☢☢☢ 1-10 mSv 1 1 15 1 1 0 0 0 0 0 0
Appendix Key

A more complete discussion of the items presented below can be found by accessing the supporting documents at the designated hyperlinks.

Appropriateness Category:The panel’s recommendation for a procedure based on the assessment of the risks and benefits of performing the procedure for the specified clinical scenario.

SOE: Strength of Evidence. The assessment of the amount and quality of evidence found in the peer reviewed medical literature for an appropriateness recommendation.

  • References: The citation number and PMID for the reference(s) associated with the recommendation.
  • Study Quality: The assessment of the quality of an individual reference based on the number of study quality elements described in the reference.

RRL: Relative Radiation Level. A population based assessment of the amount of radiation a typical patient may be exposed to during the specified procedure.

Rating: The final rating (1-9 scale) for the procedure as determined by the panel during rating rounds.

Median: The median rating (1-9 scale) for the procedure as determined by the panel during rating rounds.

Final tabulations: A histogram showing the number of panel members who rated the procedure as noted in the column heading (ie, 1, 2, 3, etc.).

Additional supporting documents about the AC methodology and processes can be found at www.acr.org/ac.