Variant 1: Suspected acute pyelonephritis. First-time presentation. Uncomplicated patient (eg, no history of pyelonephritis, diabetes, immune compromise, history of stones or renal obstruction, prior renal surgery, advanced age, vesicoureteral reflux, lack of response to therapy, or pregnancy). Initial imaging.
Variant 2: Suspected acute pyelonephritis. Complicated patient (eg, recurrent pyelonephritis, diabetes, immune compromise, advanced age, vesicoureteral reflux, or lack of response to initial therapy). Initial imaging.
1
2
3
4
5
6
7
8
9
CT abdomen and pelvis with IV contrast
Usually appropriate
Limited
☢☢☢ 1-10 mSv
☢☢☢☢ 3-10 mSv [ped]
8
8
1
0
0
0
1
1
1
5
8
References
Study Quality
15 (18203942)
4
14 (2655002)
4
21 (7789019)
4
20 (3883000)
4
8 (30392592)
4
18 (28525662)
4
17 (30708379)
3
19 (30224907)
3
1 (29298155)
4
2 (17599303)
4
10 (28271650)
4
16 (22859793)
4
US abdomen
May be appropriate
Strong
O 0 mSv
O 0 mSv [ped]
5
5
0
0
0
2
12
3
0
0
0
References
Study Quality
37 (21792579)
4
39 (17941932)
2
38 (11149528)
3
10 (28271650)
4
36 (20428429)
2
US color Doppler kidneys and bladder retroperitoneal
May be appropriate
Strong
O 0 mSv
O 0 mSv [ped]
6
6
1
0
0
5
0
5
5
1
0
References
Study Quality
41 (12592126)
1
37 (21792579)
4
42 (15241674)
1
40 (10961277)
4
38 (11149528)
3
10 (28271650)
4
36 (20428429)
2
MRI abdomen and pelvis without and with IV contrast
May be appropriate
Strong
O 0 mSv
O 0 mSv [ped]
5
5
1
1
0
2
9
3
1
0
0
References
Study Quality
29 (23887662)
3
27 (23884301)
2
30 (23749224)
3
28 (24443116)
3
14 (2655002)
4
20 (3883000)
4
8 (30392592)
4
31 (27229497)
4
32 (19711638)
4
MRI abdomen and pelvis without IV contrast
May be appropriate
Strong
O 0 mSv
O 0 mSv [ped]
4
4
1
2
5
7
2
0
0
0
0
References
Study Quality
29 (23887662)
3
27 (23884301)
2
30 (23749224)
3
28 (24443116)
3
14 (2655002)
4
20 (3883000)
4
8 (30392592)
4
31 (27229497)
4
32 (19711638)
4
CT abdomen and pelvis without IV contrast
May be appropriate
Limited
☢☢☢ 1-10 mSv
☢☢☢☢ 3-10 mSv [ped]
4
4
3
3
2
1
6
2
0
0
0
References
Study Quality
15 (18203942)
4
14 (2655002)
4
21 (7789019)
4
20 (3883000)
4
8 (30392592)
4
18 (28525662)
4
17 (30708379)
3
19 (30224907)
3
1 (29298155)
4
2 (17599303)
4
10 (28271650)
4
16 (22859793)
4
CT abdomen with IV contrast
May be appropriate (Disagreement)
Expert Opinion
☢☢☢ 1-10 mSv
☢☢☢☢ 3-10 mSv [ped]
5
5
4
1
3
3
2
4
0
0
0
References
Study Quality
15 (18203942)
4
14 (2655002)
4
21 (7789019)
4
20 (3883000)
4
8 (30392592)
4
18 (28525662)
4
17 (30708379)
3
19 (30224907)
3
1 (29298155)
4
16 (22859793)
4
CT abdomen and pelvis without and with IV contrast
May be appropriate (Disagreement)
Expert Opinion
☢☢☢☢ 10-30 mSv
☢☢☢☢☢ 10-30 mSv [ped]
5
5
2
2
4
0
3
1
3
2
0
References
Study Quality
15 (18203942)
4
14 (2655002)
4
21 (7789019)
4
20 (3883000)
4
8 (30392592)
4
18 (28525662)
4
17 (30708379)
3
19 (30224907)
3
1 (29298155)
4
2 (17599303)
4
10 (28271650)
4
16 (22859793)
4
Fluoroscopy voiding cystourethrography
Usually not appropriate
Limited
☢☢ 0.1-1mSv
☢☢ 0.03-0.3 mSv [ped]
1
1
10
4
2
0
0
0
0
1
0
References
Study Quality
25 (22040289)
2
26 (15993478)
4
Fluoroscopy antegrade pyelography
Usually not appropriate
Limited
☢☢☢ 1-10 mSv
1
1
13
2
1
0
0
0
0
1
0
References
Study Quality
15 (18203942)
4
Radiography abdomen and pelvis
Usually not appropriate
☢☢☢ 1-10 mSv
☢☢☢ 0.3-3 mSv [ped]
1
n/a
0
0
0
0
0
0
0
0
0
Radiography intravenous urography
Usually not appropriate
Limited
☢☢☢ 1-10 mSv
☢☢☢ 0.3-3 mSv [ped]
1
1
13
2
1
0
0
0
0
1
0
References
Study Quality
15 (18203942)
4
MRI abdomen without and with IV contrast
Usually not appropriate
Expert Consensus
O 0 mSv
O 0 mSv [ped]
3
3
4
1
4
0
8
0
0
0
0
MRI abdomen without IV contrast
Usually not appropriate
Expert Consensus
O 0 mSv
O 0 mSv [ped]
3
3
5
2
4
4
2
0
0
0
0
MRU without and with IV contrast
Usually not appropriate
Limited
O 0 mSv
O 0 mSv [ped]
3
3
6
1
2
1
7
0
0
0
0
References
Study Quality
33 (24128878)
3
34 (20531092)
4
35 (14975495)
1
MRU without IV contrast
Usually not appropriate
Limited
O 0 mSv
O 0 mSv [ped]
1
1
9
1
7
0
0
0
0
0
0
References
Study Quality
33 (24128878)
3
34 (20531092)
4
35 (14975495)
1
CT abdomen without IV contrast
Usually not appropriate
Limited
☢☢☢ 1-10 mSv
☢☢☢☢ 3-10 mSv [ped]
2
2
7
3
6
1
0
0
0
0
0
References
Study Quality
15 (18203942)
4
14 (2655002)
4
21 (7789019)
4
20 (3883000)
4
8 (30392592)
4
18 (28525662)
4
17 (30708379)
3
19 (30224907)
3
1 (29298155)
4
16 (22859793)
4
DMSA renal scan
Usually not appropriate
Limited
☢☢☢ 1-10 mSv
☢☢☢ 0.3-3 mSv [ped]
1
1
9
2
6
0
0
0
0
0
0
References
Study Quality
23 (23414827)
4
24 (10966194)
4
CT abdomen without and with IV contrast
Usually not appropriate
Limited
☢☢☢☢ 10-30 mSv
☢☢☢☢☢ 10-30 mSv [ped]
3
3
4
3
2
1
5
2
0
0
0
References
Study Quality
15 (18203942)
4
14 (2655002)
4
21 (7789019)
4
20 (3883000)
4
8 (30392592)
4
18 (28525662)
4
17 (30708379)
3
19 (30224907)
3
1 (29298155)
4
16 (22859793)
4
CTU without and with IV contrast
Usually not appropriate
Expert Consensus
☢☢☢☢ 10-30 mSv
☢☢☢☢☢ 10-30 mSv [ped]
3
3
4
1
10
1
1
0
0
0
0
Variant 3: Suspected acute pyelonephritis. History of renal stones or renal obstruction. Initial imaging.
1
2
3
4
5
6
7
8
9
CT abdomen and pelvis with IV contrast
Usually appropriate
Limited
☢☢☢ 1-10 mSv
☢☢☢☢ 3-10 mSv [ped]
8
8
1
1
0
0
0
2
2
5
6
References
Study Quality
15 (18203942)
4
22 (27563103)
2
14 (2655002)
4
21 (7789019)
4
20 (3883000)
4
8 (30392592)
4
18 (28525662)
4
17 (30708379)
3
19 (30224907)
3
1 (29298155)
4
10 (28271650)
4
11 (-3194118)
4
16 (22859793)
4
CT abdomen and pelvis without and with IV contrast
Usually appropriate
Limited
☢☢☢☢ 10-30 mSv
☢☢☢☢☢ 10-30 mSv [ped]
8
8
0
0
0
0
0
0
5
10
2
References
Study Quality
15 (18203942)
4
22 (27563103)
2
14 (2655002)
4
21 (7789019)
4
20 (3883000)
4
8 (30392592)
4
18 (28525662)
4
17 (30708379)
3
19 (30224907)
3
1 (29298155)
4
10 (28271650)
4
11 (-3194118)
4
16 (22859793)
4
US abdomen
May be appropriate
Strong
O 0 mSv
O 0 mSv [ped]
5
5
0
0
0
1
8
7
0
1
0
References
Study Quality
37 (21792579)
4
39 (17941932)
2
38 (11149528)
3
10 (28271650)
4
36 (20428429)
2
44 (12819343)
4
45 (23091240)
4
US color Doppler kidneys and bladder retroperitoneal
May be appropriate
Strong
O 0 mSv
O 0 mSv [ped]
6
6
1
0
0
1
3
8
3
1
0
References
Study Quality
41 (12592126)
1
37 (21792579)
4
42 (15241674)
1
40 (10961277)
4
38 (11149528)
3
10 (28271650)
4
36 (20428429)
2
44 (12819343)
4
45 (23091240)
4
MRI abdomen and pelvis without and with IV contrast
May be appropriate
Limited
O 0 mSv
O 0 mSv [ped]
5
5
1
1
2
4
6
3
0
0
0
References
Study Quality
29 (23887662)
3
30 (23749224)
3
28 (24443116)
3
14 (2655002)
4
8 (30392592)
4
31 (27229497)
4
32 (19711638)
4
MRI abdomen and pelvis without IV contrast
May be appropriate
Limited
O 0 mSv
O 0 mSv [ped]
4
4
1
4
0
9
2
1
0
0
0
References
Study Quality
29 (23887662)
3
30 (23749224)
3
28 (24443116)
3
14 (2655002)
4
8 (30392592)
4
31 (27229497)
4
32 (19711638)
4
CT abdomen and pelvis without IV contrast
May be appropriate
Limited
☢☢☢ 1-10 mSv
☢☢☢☢ 3-10 mSv [ped]
6
6
0
0
2
0
4
6
2
2
1
References
Study Quality
15 (18203942)
4
22 (27563103)
2
14 (2655002)
4
21 (7789019)
4
20 (3883000)
4
8 (30392592)
4
18 (28525662)
4
17 (30708379)
3
19 (30224907)
3
1 (29298155)
4
10 (28271650)
4
11 (-3194118)
4
16 (22859793)
4
CT abdomen without and with IV contrast
May be appropriate (Disagreement)
Expert Opinion
☢☢☢☢ 10-30 mSv
☢☢☢☢☢ 10-30 mSv [ped]
5
5
4
0
4
3
0
6
0
0
0
References
Study Quality
15 (18203942)
4
14 (2655002)
4
21 (7789019)
4
20 (3883000)
4
8 (30392592)
4
18 (28525662)
4
17 (30708379)
3
19 (30224907)
3
1 (29298155)
4
16 (22859793)
4
Fluoroscopy voiding cystourethrography
Usually not appropriate
Limited
☢☢ 0.1-1mSv
☢☢ 0.03-0.3 mSv [ped]
1
1
12
3
1
0
0
0
0
1
0
References
Study Quality
15 (18203942)
4
Fluoroscopy antegrade pyelography
Usually not appropriate
Limited
☢☢☢ 1-10 mSv
1
1
12
3
0
1
0
0
0
1
0
References
Study Quality
15 (18203942)
4
Radiography abdomen and pelvis
Usually not appropriate
☢☢☢ 1-10 mSv
☢☢☢ 0.3-3 mSv [ped]
2
n/a
0
0
0
0
0
0
0
0
0
Radiography intravenous urography
Usually not appropriate
Limited
☢☢☢ 1-10 mSv
☢☢☢ 0.3-3 mSv [ped]
1
1
13
3
0
0
0
0
0
1
0
References
Study Quality
15 (18203942)
4
MRI abdomen without and with IV contrast
Usually not appropriate
Limited
O 0 mSv
O 0 mSv [ped]
3
3
5
1
4
5
2
0
0
0
0
References
Study Quality
31 (27229497)
4
32 (19711638)
4
MRI abdomen without IV contrast
Usually not appropriate
Limited
O 0 mSv
O 0 mSv [ped]
3
3
7
1
7
2
0
0
0
0
0
References
Study Quality
31 (27229497)
4
32 (19711638)
4
MRU without and with IV contrast
Usually not appropriate
Limited
O 0 mSv
O 0 mSv [ped]
2
2
6
3
3
5
0
0
0
0
0
References
Study Quality
31 (27229497)
4
32 (19711638)
4
43 (29399012)
3
MRU without IV contrast
Usually not appropriate
Limited
O 0 mSv
O 0 mSv [ped]
2
2
8
2
2
4
1
0
0
0
0
References
Study Quality
31 (27229497)
4
32 (19711638)
4
43 (29399012)
3
CT abdomen with IV contrast
Usually not appropriate
Limited
☢☢☢ 1-10 mSv
☢☢☢☢ 3-10 mSv [ped]
3
3
4
0
6
1
5
1
0
0
0
References
Study Quality
15 (18203942)
4
14 (2655002)
4
21 (7789019)
4
20 (3883000)
4
8 (30392592)
4
18 (28525662)
4
17 (30708379)
3
19 (30224907)
3
1 (29298155)
4
16 (22859793)
4
CT abdomen without IV contrast
Usually not appropriate
Limited
☢☢☢ 1-10 mSv
☢☢☢☢ 3-10 mSv [ped]
3
3
4
3
3
6
1
0
0
0
0
References
Study Quality
15 (18203942)
4
14 (2655002)
4
21 (7789019)
4
20 (3883000)
4
8 (30392592)
4
18 (28525662)
4
17 (30708379)
3
19 (30224907)
3
1 (29298155)
4
16 (22859793)
4
DMSA renal scan
Usually not appropriate
Limited
☢☢☢ 1-10 mSv
☢☢☢ 0.3-3 mSv [ped]
2
2
7
2
3
3
1
0
0
1
0
References
Study Quality
24 (10966194)
4
CTU without and with IV contrast
Usually not appropriate
Expert Consensus
☢☢☢☢ 10-30 mSv
☢☢☢☢☢ 10-30 mSv [ped]
3
3
5
1
4
0
5
1
1
0
0
Variant 4: Suspected acute pyelonephritis. Pregnant female with no other complications (eg, no history of diabetes, immune compromise, history of stones or renal obstruction, prior renal surgery, vesicoureteral reflux, or lack of response to therapy). Initial imaging.
Variant 5: Suspected acute pyelonephritis. History of pelvic renal transplant with native kidneys in situ and no other complications (eg, no history of pyelonephritis, diabetes, history of stones or renal obstruction, prior renal surgery, advanced age, vesicoureteral reflux, lack of response to therapy, or pregnancy). Initial imaging.
Appendix Key
A more complete discussion of the items presented below can be found by accessing the supporting
documents at the designated hyperlinks.
Appropriateness Category: The panel’s recommendation for a procedure based on the assessment of the
risks and benefits of performing the procedure for the specified clinical scenario.
SOE:
Strength of Evidence. The assessment of the amount and quality of evidence found in the peer
reviewed medical literature for an appropriateness recommendation.
References: The citation number and PMID for the reference(s) associated with the recommendation.
Study Quality: The assessment of the quality of an individual reference based on the number
of study quality elements described in the reference.
RRL:
Relative Radiation Level. A population based assessment of the amount of radiation a typical patient
may be exposed to during the specified procedure.
Rating: The final rating (1-9 scale) for the procedure as determined by the panel during rating rounds.
Median:
The median rating (1-9 scale) for the procedure as determined by the panel during rating rounds.
Final tabulations:
A histogram showing the number of panel members who rated the procedure as noted in
the column heading (ie, 1, 2, 3, etc.).
Additional supporting documents about the AC methodology and processes can be found at www.acr.org/ac.