| 1. Harber P, Redlich CA, Henneberger PK. Work-Related Lung Diseases. Am J Respir Crit Care Med. 193(2):P3-4, 2016 Jan 15. |
Review/Other-Dx |
N/A |
No abstract available. |
No abstract available. |
4 |
| 2. Tarlo SM, Altman KW, Oppenheimer J, et al. Occupational and Environmental Contributions to Chronic Cough in Adults: Chest Expert Panel Report. [Review]. Chest. 150(4):894-907, 2016 Oct. |
Review/Other-Dx |
N/A |
To review occupational and environmental contributions to chronic cough in adults, focusing on aspects not previously covered in the 2006 ACCP Cough Guideline or our more recent systematic review, and suggest an approach to investigation of these factors when suspected. |
The literature review identified relevant articles regarding: mechanisms; allergic environmental causes; chronic cough and the recreational and involuntary inhalation of tobacco and marijuana smoke; nonallergic environmental triggers; laryngeal syndromes; and occupational diseases and exposures. Consensus-based statements were developed for the approach to diagnosis due to a lack of strong evidence from published literature. |
4 |
| 3. Gibson GJ, Loddenkemper R, Lundback B, Sibille Y. Respiratory health and disease in Europe: the new European Lung White Book. Eur Respir J. 42(3):559-63, 2013 Sep. |
Review/Other-Dx |
N/A |
No abstract available- Book chapter |
No abstract available. |
4 |
| 4. Graber JM, Harris G, Almberg KS, Rose CS, Petsonk EL, Cohen RA. Increasing Severity of Pneumoconiosis Among Younger Former US Coal Miners Working Exclusively Under Modern Dust-Control Regulations. J Occup Environ Med. 59(6):e105-e111, 2017 Jun. |
Review/Other-Dx |
24686 patients |
To estimate the respiratory disease burden among former US Coal miners working exclusively under modern dust-control regulations. |
Among 24,686 claimants, 8.5% had advanced CWP/PMF; prevalence was highest among younger (less than or equal to 56 years: 10.8%) and older (greater than 70 years: 8.4%) miners and those who began work after versus before 1970 (8.3% vs. 4.0%). |
4 |
| 5. Reynolds LE, Blackley DJ, Laney AS, Halldin CN. Respiratory morbidity among U.S. coal miners in states outside of central Appalachia. Am J Ind Med. 60(6):513-517, 2017 Jun. |
Observational-Dx |
7949 coal miners |
To characterize the respiratory health of this understudied population, analyzed ECWHSP data collected from active underground and surface miners working in the eastern (excluding central Appalachia), interior, and western coal mining regions |
A total of 103 (2.1%) miners had CWP. The eastern region had the highest prevalence (3.4%), followed by the western (1.7%), and interior (0.8%) regions. A total of 524 (9.3%) miners had abnormal spirometry. |
3 |
| 6. Grubstein A, Shtraichman O, Fireman E, Bachar GN, Noach-Ophir N, Kramer MR. Radiological Evaluation of Artificial Stone Silicosis Outbreak: Emphasizing Findings in Lung Transplant Recipients. J Comput Assist Tomogr. 40(6):923-927, 2016 Nov/Dec. |
Observational-Dx |
82 marble workers |
To describe the computed tomography (CT) findings and correlate pulmonary function tests (PFTs) of silicosis patients with emphasis on the findings in lung transplantation (LTX) recipients. |
A statistically significant inverse relationship was found between chest CT scores and PFT including forced expired volume in the first second (r = -0.54, P < 0.0001), total lung capacity (r = -0.4, P < 0.0001), and diffusion capacity for carbon monoxide single breath % (r = -0.6, P < 0.0001) parameters. Progressive massive fibrosis indicating advanced and complicated silicosis was found in 85% of LTX patients, as compared with 40% in patients with maintained pulmonary function. Ground-glass opacities were seen in some LTX patients with or without signs of progressive massive fibrosis. Two of these patients had silicoproteinosis diagnosed within the resected lung, indicating an acute or accelerated form of silicosis. |
3 |
| 7. Dumavibhat N, Matsui T, Hoshino E, et al. Radiographic progression of silicosis among Japanese tunnel workers in Kochi. J Occup Health. 55(3):142-8, 2013. |
Observational-Dx |
65 patients |
To investigate the natural course of silicosis in terms of radiographic progression among Japanese tunnel workers. |
A total of 65 patients, who were no longer exposed to silica for the duration of the study, were included. The mean age at the first visit was 58.60 ± 7.10 years. The incidence rate of progression was 42 per 1,000 person-years with a median time to progression of 17 years. Progression was demonstrated among 33 cases (51%). The mean durations of progression from category 1 to category 4 and category 2 to category 4 were 14.55 and 10.65 years, respectively. Most patients (86%) had radiographic change from category 1 or 2 directly to category 4. |
3 |
| 8. Akgun M, Araz O, Ucar EY, et al. Silicosis Appears Inevitable Among Former Denim Sandblasters: A 4-Year Follow-up Study. Chest. 148(3):647-654, 2015 Sep. |
Observational-Dx |
145 sandblasters |
To reevaluate former sandblasters studied in 2007 for incident silicosis, radiographic progression, pulmonary function loss, and mortality and to examine any associations between these outcomes and previously demonstrated risk factors for silicosis. |
Among the 145 former sandblasters studied in 2007, 83 were reassessed in 2011. In the 4-year follow-up period, nine (6.2%) had died at a mean age of 24 years. Of the 74 living sandblasters available for reexamination, the prevalence of silicosis increased from 55.4% to 95.9%. Radiographic progression, observed in 82%, was associated with younger age, never smoking, foreman work, and sleeping at the workplace. Pulmonary function loss, seen in 66%, was positively associated with never smoking and higher initial FVC % predicted. Death was associated with never smoking, foreman work, number of different denim-sandblasting places of work, sleeping at the workplace, and lower pulmonary function, of which only the number of diff erent places worked remained in multivariate analyses. |
1 |
| 9. Blackley DJ, Halldin CN, Wang ML, Laney AS. Small mine size is associated with lung function abnormality and pneumoconiosis among underground coal miners in Kentucky, Virginia and West Virginia. Occup Environ Med. 71(10):690-4, 2014 Oct. |
Observational-Dx |
3771 miners |
To describe the prevalence of lung function abnormality and coal workers’ pneumoconiosis (CWP) by mine size among underground coal miners in Kentucky, Virginia and West Virginia. |
Among 3771 eligible miners, those from small mines were more likely to have abnormal spirometry (18.5% vs 13.8%, p<0.01), CWP (10.8% vs 5.2%, p<0.01) and progressive massive fibrosis (2.4% vs 1.1%, p<0.01). In regression analysis, working in a small mine was associated with 37% higher prevalence of abnormal spirometry (PR 1.37, 95% CI 1.16 to 1.61) and 2.1 times higher prevalence of CWP (95% CI 1.68 to 2.70). |
4 |
| 10. Alici NS, Cimrin A, Coskun Beyan A. Pneumoconiosis in different sectors and their differences in Turkey. Tuberk. Toraks. 64(4):275-282, 2016 Dec. |
|
|
To review risk factors for pneumoconiosis, evaluate functional and radiological findings in different sectors. |
60 were young males. Twenty-four of the cases (39.3%) worked at dental technician, 24 cases (39.3%) were ceramic workers, 5 cases (8.2%) were sandblasters, 2 cases (3.3%) were welders, 3 cases (4.9%) were miners, and 3 cases (4.9%) were marble cutters. The sectors in which the exposure started at the earliest ages were dental technicians and sandblasters, while the shortest working time was in sandblasting. The dental technicians were younger than the ceramic workers at the age of diagnosis (Kruskall-Wallis p= 0.003). The exposure time of the sandblasters was significantly shorter, especially than the ceramic workers (Kruskall-Wallis p= 0.002). The cases have been referred to us with pneumoconiosis suspicion based on the radiographic findings in the PA chest roentgenogram performed during the periodic examinations at their work place; but unlike other studies, in our study, following the HRCT assessment, cases which did not present any visible pathology in the re-evaluation of their PA chest roentgenogram, but had HRCT findings have been diagnosed as pneumoconiosis. Among the 44 cases in which micro-nodules had been detected at their HRCT, 15 of them had been previously classified as profusion of small opacities 0/1 according to their PA chest roentgenogram findings. It has been seen that the HRCT findings differ among sectors. Ceramics workers and sandblasters had significantly more micro-nodules, while dental technicians had significantly more mediastinal lymphadenopathies (Chi square, p= 0.004 and p= 0.007 respectively). When the relationship between the existence of big opacities and complaints was studied, statistically significant weight loss was detected in cases which had C opacities (chi square p= 0.01). Statistically significant FEV1 decrease was observed in cases which had weight loss (independent samples t-test p= 0.046). It has been observed that when the profusion of small opacities increased, while there was no statistically significant functional status change in non-smokers, a significant functional impairment was observed in smokers. |
|
| 11. Wade WA, Petsonk EL, Young B, Mogri I. Severe occupational pneumoconiosis among West Virginian coal miners: one hundred thirty-eight cases of progressive massive fibrosis compensated between 2000 and 2009. Chest. 139(6):1458-1462, 2011 Jun. |
Review/Other-Dx |
138 miners |
To describe the pattern and progression of disease based on West Virginia State Occupational Pneumoconiosis Board (WVSOPB) records available for 138 West Virginia underground coal miners with Progressive massive fibrosis (PMF) whose pneumoconiosis claims were awarded between 2000 and 2009. |
PMF, a complication of CWP, developed in 138 West Virginian coal miners at a mean age of 52.6 years after an average of 30 years work tenure. The time of progression averaged 12.2 years from the last normal chest radiograph until PMF was detected. Lung function declined sharply in both smokers and nonsmokers, averaging 87 mL/y for FEV 1 and 74 mL/y for FVC. The board has confirmed 21 deaths in this group. The most common job activities were operating continuous-mining machines (41%) and roof bolting (19%). Virtually all of these miners’ dust exposures occurred after the implementation of current federal dust regulations. |
4 |
| 12. Schaal M, Severac F, Labani A, Jeung MY, Roy C, Ohana M. Diagnostic Performance of Ultra-Low-Dose Computed Tomography for Detecting Asbestos-Related Pleuropulmonary Diseases: Prospective Study in a Screening Setting. PLoS ONE. 11(12):e0168979, 2016. |
Observational-Dx |
55 patients |
To evaluate the diagnostic performance of Ultra-Low-Dose Chest CT (ULD CT) for the detection of any asbestos-related lesions (primary endpoint) and specific asbestos-related abnormalities, i.e. non-calcified and calcified pleural plaques, diffuse pleural thickening, asbestosis and significant lung nodules (secondary endpoints). |
Radiation dose was 17.9±1.2mGy.cm (0.25mSv) for the ULD-CT versus 288.8 ±151mGy. cm (4mSv); p <2.2e-16. Prevalence of abnormalities was 20%. The ULD CT's diagnostic performance in joint reading was high for the primary endpoint (sensitivity = 90.9%, specificity = 100%, positive predictive value = 100%, negative predictive value = 97.8%), high for lung nodules, diffuse pleural thickening and calcified pleural plaques (sensitivity, specificity, PPV and NPV = 100%) and fair for asbestosis (sensitivity = 75%, specificity = 100%, PPV = 00%, NPV = 98.1%). Intra-reader accuracy between the ULD CT and the reference CT for the primary endpoint was 98% for the senior and 100% for the junior radiologist. Inter-reader agreement for the primary endpoint was almost perfect (Cohen's Kappa of 0.81). |
1 |
| 13. Murray CP, Wong PM, Teh J, et al. Ultra low dose CT screen-detected non-malignant incidental findings in the Western Australian Asbestos Review Programme. Respirology. 21(8):1419-1424, 2016 11. |
Review/Other-Dx |
906 subjects |
To describe the prevalence of indeterminate pulmonary nodules and incidental findings on chest low dose CT (LDCT) of asbestos exposed subjects in Western Australia. |
Subjects were mostly (81%) men with a median age of 70 years. Fifty-eight (6.5%) participants were current smokers, 511 (56.4%) ex-smokers and 325 (36.4%) never-smokers. One hundred and four indeterminate nodules were detected in 77 subjects (8.5%); of these, eight cases had confirmed lung cancer (0.88%). Eighty-seven subjects (9.6%) had incidental findings that required further investigation, 42 (4.6%) from lower airways inflammation. The majority of nodules were solid, 4–6mm and more common with age. Five hundred and eighty (64%) subjects had pleural plaques, and 364 (40.2%) had evidence of interstitial lung disease. |
4 |
| 14. Macia-Suarez D, Sanchez-Rodriguez E, Lopez-Calvino B, Diego C, Pombar M. Low-voltage chest CT: another way to reduce the radiation dose in asbestos-exposed patients. Clin Radiol. 72(9):797.e1-797.e10, 2017 Sep. |
Observational-Dx |
56 participants |
To assess whether low voltage chest computed tomography (CT) can be used to successfully diagnose disease in patients with asbestos exposure. |
A good correlation between routine and low-dose CT was demonstrated for most parameters with a mean radiation dose reduction of up to 83% of the effective dose based on the dose-length product between protocols. |
2 |
| 15. Ates I, Yucesoy B, Yucel A, Suzen SH, Karakas Y, Karakaya A. Possible effect of gene polymorphisms on the release of TNFalpha and IL1 cytokines in coal workers' pneumoconiosis. Exp Toxicol Pathol. 63(1-2):175-9, 2011 Jan. |
Observational-Dx |
67 patients and 92 controls |
To investigate TNFA, IL1A, IL1B and IL1RA genes variations on basal, lipopolysaccharide and coal dustinduced cytokine release from blood monocytes of homozygous allele and minor variant allele carriers in Turkish coal workers and coal workers’ pneumoconiosis (CWP) patients. |
According to the genotyping results, TNFA –238 gene polymorphism was found as a risk factor in CWP development (OR=3.79) and to in vitro results; release of both TNF-alpha and IL1 cytokines from the monocytes in CWP patients was significantly increased compared to the healthy workers. Also, LPS and coal dust stimulated release of TNF-alpha, which was significantly higher in allele 2 carriers compared to subjects carrying allele 1 in both the groups. |
3 |
| 16. Braz NF, Carneiro AP, Amorim MR, et al. Association between inflammatory biomarkers in plasma, radiological severity, and duration of exposure in patients with silicosis. J Occup Environ Med. 56(5):493-7, 2014 May. |
Observational-Dx |
57 patients |
To evaluate the plasma levels of CCL2, CCL3, CCL11, CCL24, tumor necrosis factor alpha, sTNFR1, and sTNFR2 in subjects exposed to silica (SES) with and without silicosis compared with unexposed reference control group, and their associations with the radiological severity and duration of exposure to silica. |
CCL3, CCL24, sTNFR1, and sTNFR2 were increased in SES and in SES with silicosis than in controls. There were no differences in the levels of CCL2, CCL11, or tumor necrosis factor alpha. The sTNFR2 level was greater in SES with silicosis than in SES without silicosis. There was a positive correlation between sTNFR1 and sTNFR2 and the radiological severity and time of exposure to silica. sTNFR2 was associated with all categories of radiological severity. |
2 |
| 17. Liu SJ, Wang P, Jiao J, Han L, Lu YM. Differential gene expression associated with inflammation in peripheral blood cells of patients with pneumoconiosis. J Occup Health. 58(4):373-80, 2016 Jul 22. |
Observational-Dx |
44 patients and 49 controls |
To study expression changes in inflammation-related genes in peripheral blood of patients with pneumoconiosis and to explore the possibility of these genes as pneumoconiosis biomarkers. |
The expression of 11 genes was significantly altered in patients with pneumoconiosis compared with those of the control. Among these 11 genes, 8 genes were upregulated and 3 were downregulated. Preliminary results indicated that interleukin 6 (IL- 6) mRNA expression in patients with pneumoconiosis was higher than that in controls (P=0.019). The level of IL6 mRNA expression in the patients was higher than that in non-smoking controls, but it was neither affected by type and stage of pneumoconiosis nor by time of contact with dust. |
3 |
| 18. Okamoto T, Fujii M, Furusawa H, Tsuchiya K, Miyazaki Y, Inase N. The usefulness of KL-6 and SP-D for the diagnosis and management of chronic hypersensitivity pneumonitis. Respir Med. 109(12):1576-81, 2015 Dec. |
Observational-Dx |
35 patients with acute HP, 57 with chronic HP, 54 with IPF, 67 with
CVD-IP, and 47 with sarcoidosis |
To clarify the usefulness of serum Krebs von den Lungen-6 (KL-6) and surfactant protein D (SP-D) for the diagnosis and management of chronic hypersensitivitypneumonitis (HP). |
Serum KL-6 and SP-D levels in acute HP (2710 U/ml and 338 ng/ml, median) and chronic HP (1500 U/ml and 264 ng/ml, median) were significantly higher than in IPF, CVD-IP, and sarcoidosis. The area under the curve (AUC) values for serum KL-6 and SP-D between chronic HP and IPF were 0.771 and 0.729, respectively. Serum KL-6 levels in chronic HP were significantly higher during episodes of acute exacerbation than 1 month before acute exacerbation. The serum KL-6 levels had correlations with serum SP-D and the percentage of lymphocytes in bronchoalveolar lavage fluid. |
3 |
| 19. Yu B, Yang X, Li F, Wu C, Wang W, Ding W. Significance of Foxp3+CD4+ regulatory T cells in the peripheral blood of Uygur patients in the acute and chronic phases of pigeon breeder's lung. Bosn. j. basic med. sci.. 17(1):17-22, 2017 Feb 21. |
Observational-Dx |
32 cases and 30 controls |
To evaluate the significance of Foxp3+CD4+ regulatory T cells in the peripheral blood of Uygur patients in the acute and chronic phases of pigeon breeder's lung. |
In both PBL groups, the Foxp3+CD4+ Treg and CD4+CD25+ and CD4+CD3+ T cell percentages and CD4+/CD8+ ratios were significantly lower than in the control group (p < 0.01). In the PBL groups, particularly the acutephase group, the CD8+CD3+ T lymphocyte percentage was significantly higher than in the control group (p < 0.01). There were no significant differences in CD4+CD25+ cells between the PBL groups. In peripheral blood from the PBL groups, the CD4+/CD8+ ratio was positively correlated with the Foxp3+CD4+ Treg (r = 0.864, p < 0.05) and CD4+/CD25+ cell (r = 0.34, p < 0.05) percentages. Low Foxp3+CD4+ Treg expression or overconsumption may be a pathogenic factor in PBL. |
3 |
| 20. Lee JS, Shin JH, Lee KM, et al. Serum levels of TGF-beta1 and MCP-1 as biomarkers for progressive coal workers' pneumoconiosis in retired coal workers: a three-year follow-up study. Ind Health. 52(2):129-36, 2014. |
Observational-Dx |
85 patients |
To examine the relationships between coal workers’ pneumoconiosis (CWP) progression over a 3 yr period and the serum levels of cytokines in 85retired coal workers. |
Median levels of TGF-ß1 and MCP-1 were significantly higher in subjects with progressive CWP than in those without CWP progression. The area under the ROC curve for TGF-ß1 (0.693) and MCP-1 (0.653) indicated that these cytokines could serve as biomarkers for the progression of CWP. Serum TGF-ß1 levels were related to the progression of CWP (ß=0.247, p=0.016). The results suggest that high serum levels of TGF-ß1 and MCP-1 are associated with the progression of CWP. |
3 |
| 21. Berk S, Dogan DO, Gumus C, Akkurt I. Relationship between radiological (X-ray/HRCT), spirometric and clinical findings in dental technicians' pneumoconiosis. The clinical respiratory journal. 10(1):67-73, 2016 Jan. |
Observational-Dx |
32 dental technicians |
To evaluate clinical, functional and radiological impacts of exposure to dust on respiratory functions via chest X-ray (CXR), high-resolution computed tomography (HRCT) and spirometry in dental technicians. |
The mean age of the study population was 31?±?9 years and mean employment duration was 14?±?9 years. Twenty-two (69%) technicians had a history of smoking. The most common symptom was phlegm, while dyspnea prevalence was higher in those with an elevated International Labour Office (ILO) profusion score (P<0.01). Parenchymal opacities were determined in 10 (31%) technicians by CXR and in 22 (69%) technicians by HRCT (P<0.01). There was a positive correlation between ILO profusion score and HRCT score (r=0.765, P<0.01). ILO profusion score and HRCT score showed positive correlation with employment duration (r=0.599, P=0.01; r=0.514, P=0.01, respectively), while exhibiting negative correlation with FVC (r=-0.509, P<0.05; r=-0.627, P=0.01 respectively), FVC% (r=-0.449, P<0.05; r=-0.457, P<0.05, respectively) and forced expiratory volume in 1 s (r=-0.473, P<0.05; r=-0.598, P=0.01, respectively). |
2 |
| 22. Chiba S, Tsuchiya K, Akashi T, et al. Chronic Hypersensitivity Pneumonitis With a Usual Interstitial Pneumonia-Like Pattern: Correlation Between Histopathologic and Clinical Findings. Chest. 149(6):1473-81, 2016 06. |
Observational-Dx |
16 patients |
To determine the relationship between clinical, radiologic, and histopathologic findings of chronic hypersensitivity pneumonitis (HP). |
The extent of centrilobular fibrosis was negatively correlated with Pao2 (r = -0.55, P = .03). The extent of bridging fibrosis was positively correlated with the ratio of maximal expiratory flow at 50% of forced vital capacity to that at 25% (r = 0.60, P = .02). Patients with a greater extent of fibroblastic foci (FF) had more radiologic reticulation (P = .01), honeycombing (P = .01), and traction bronchiectasis (P = .02), and had significantly shorter survival time (P = .01) than patients with a lesser extent of FF. Multivariate analysis showed that the extent of FF was a significant prognostic factor (hazard ratio, 2.36; 95% confidence interval, 1.02-5.48; P = .04 |
2 |
| 23. Fernandez Perez ER, Swigris JJ, Forssen AV, et al. Identifying an inciting antigen is associated with improved survival in patients with chronic hypersensitivity pneumonitis. Chest. 144(5):1644-1651, 2013 Nov. |
Observational-Dx |
142 patients |
To examine whether identifying the inciting antigen (IA) impacts survival in patients with chronic hypersensitivity pneumonitis (HP). |
Of 142 patients, 67 (47%) had an identified IA, and 75 (53%) had an unidentified IA. Compared with survivors, patients who died (n 5 80, 56%) were older, more likely to have smoked, had lower total lung capacity % predicted and FVC % predicted, had higher severity of dyspnea, were more likely to have pulmonary fibrosis, and were less likely to have an identifiable IA. In a Cox PH model, the inability to identify an IA (hazard ratio [HR], 1.76; 95% CI, 1.01-3.07), older age (HR, 1.04; 95% CI, 1.01-1.07), the presences of pulmonary fibrosis (HR, 2.43; 95% CI, 1.36-4.35), a lower FVC% (HR, 1.36; 95% CI, 1.10-1.68), and a history of smoking (HR, 2.01; 95% C1, 1.15-3.50) were independent predictors of shorter survival. After adjusting for mean age, presence of fibrosis, mean FVC%, mean diffusing capacity of the lung for carbon monoxide (%), and history of smoking, survival was longer for patients with an identified IA exposure than those with an unidentified IA exposure (median, 8.75 years vs 4.88 years; P = .047). |
2 |
| 24. Fujimoto N, Gemba K, Aoe K, et al. Clinical Investigation of Benign Asbestos Pleural Effusion. Pulm Med. 2015:416179, 2015. |
Observational-Dx |
106 patients |
To clarify the association between radiological findings of DPT and respiratory function. |
There were 106 DPT patients between 2005 and 2010 [i.e. 103 men (97.2%) and 3 women (2.8%)]. The median age at diagnosis was 69 years (range 46–88). Patient occupations related to asbestos exposure included: asbestos product manufacturing (n = 17); the shipbuilding industry (n = 14); the construction industry (n = 13); heat insulation work (n = 12); plumbing, asbestos spraying, and electrical work (n = 7 each), and transportation and demolition work (n = 4 each). The median duration of asbestos exposure was 25 years (range 2–54), and the median latency period before the onset of DPT was 46 years (range 25–66). Involvement of the costophrenic angle (CPA) was also negatively correlated with the percent vital capacity (%VC; r = –0.448, p < 0.01). Pleural thickness and the craniocaudal and horizontal extension of pleural thickening, as determined by chest computed tomography (CT), were also negatively correlated with %VC (r = –0.226, p < 0.05; r = –0.409, p < 0.01, and r = –0.408, p < 0.01, respectively). |
3 |
| 25. Kumar R, Singh M. Bird fancier's lung: clinical-radiological presentation in 15 cases. Pneumonol Alergol Pol. 83(1):39-44, 2015. |
Review/Other-Dx |
15 cases |
To highlight the clinico-radiological presentation in cases of Bird fancier’s lung (BFL). |
There were a total of fifteen cases diagnosed with BFL during the study period, comprising twelve females and threemales with a mean age of 54.93 ± 14.21 years. All the studied subjects gave significant history of exposure to pigeons and werenon-smokers. The period of symptoms prior to presentation varied from one to eight years. The main symptoms on presentationwere exertional breathlessness and cough. Radiologically, diffuse centrilobular nodules, ground glassing — diffuse or patchypredominant in upper lobes, fibrosis with or without traction bronchiectasis, honeycombing, and mediastinal lymphadenopathywere seen. Bronchoscopy showed ill-defined granulomas and chronic interstitial inflammation. |
4 |
| 26. Martin SG, Kronek LP, Valeyre D, et al. High-resolution computed tomography to differentiate chronic diffuse interstitial lung diseases with predominant ground-glass pattern using logical analysis of data. Eur Radiol. 20(6):1297-310, 2010 Jun. |
Observational-Dx |
162 patients |
To evaluate the performance of high-resolution computed tomography (HRCT) to differentiate chronic diffuse interstitial lung diseases (CDILD) with predominant ground-glass pattern by using logical analysis of data (LAD). |
Models could be individualised for sarcoidosis, hypersensitivity pneumonitis, connective tissue disease and alveolar proteinosis. An additional model was individualised for drug-induced lung disease by adding clinical data. No model was demonstrated for idiopathic non-specific interstitial pneumonia and the miscellaneous category. The results showed that HRCT had a good sensitivity (>or=64%) and specificity (>or=78%) and a high negative predictive value (>or=93%) for diseases with a model. Higher sensitivity (>or=78%) and specificity (>or=89%) were achieved by adding clinical data. |
2 |
| 27. Morell F, Roger A, Reyes L, Cruz MJ, Murio C, Munoz X. Bird fancier's lung: a series of 86 patients. Medicine (Baltimore). 87(2):110-30, 2008 Mar. |
Observational-Dx |
86 patients |
To investigate into the clinical characteristics of Bird fancier's lung (BFL) in the largest series examined for this purpose by a single group, to our knowledge, taking into account the acute, subacute, or chronic clinical presentation. |
No results stated. |
2 |
| 28. Petsonk EL, Stansbury RC, Beeckman-Wagner LA, Long JL, Wang ML. Small Airway Dysfunction and Abnormal Exercise Responses. A Study in Coal Miners. Annals of the American Thoracic Society. 13(7):1076-80, 2016 07. |
Observational-Dx |
20 miners |
To investigate the implications of small airway dysfunction for exercise physiology among a group of workers exposed to coal mine dust. |
Six participants meeting criteria for small airway dysfunction were compared with 14 coal miners who did not. At submaximal workload, miners with small airway dysfunction used a higher proportion of their maximum voluntary ventilation and had higher ventilatory equivalents for both O2 and CO2. Regression modeling indicated that inefficient ventilation was significantly related to small airway dysfunction but not to FEV1 or diffusing capacity. At the end of exercise, miners with small airway dysfunction had 27% lower O2 consumption. |
3 |
| 29. Centers for Disease Control and Prevention (CDC).. Obliterative bronchiolitis in workers in a coffee-processing facility - Texas, 2008-2012. MMWR Morb Mortal Wkly Rep. 62(16):305-7, 2013 Apr 26. |
Review/Other-Dx |
N/A |
To investigate the obliterative bronchiolitis in workers in a coffee-processing facility - Texas, 2008-2012. |
No results stated |
4 |
| 30. King MS, Eisenberg R, Newman JH, et al. Constrictive bronchiolitis in soldiers returning from Iraq and Afghanistan.[Erratum appears in N Engl J Med. 2011 Nov 3;365(18):1749]. N Engl J Med. 365(3):222-30, 2011 Jul 21. |
Review/Other-Dx |
80 patients |
To investigate the constrictive bronchiolitis in soldiers returning from Iraq and Afghanistan. |
Among the soldiers who were referred for evaluation, a history of inhalational exposure to a 2003 sulfur-mine fire in Iraq was common but not universal. Of the 49 soldiers who underwent lung biopsy, all biopsy samples were abnormal, with 38 soldiers having changes that were diagnostic of constrictive bronchiolitis. In the remaining 11 soldiers, diagnoses other than constrictive bronchiolitis that could explain the presenting dyspnea were established. All soldiers with constrictive bronchiolitis had normal results on chest radiography, but about one quarter were found to have mosaic air trapping or centrilobular nodules on chest CT. The results of pulmonary-function and cardiopulmonary-exercise testing were generally within normal population limits but were inferior to those of the military control subjects. |
4 |
| 31. Kreiss K, Gomaa A, Kullman G, Fedan K, Simoes EJ, Enright PL. Clinical bronchiolitis obliterans in workers at a microwave-popcorn plant. N Engl J Med. 347(5):330-8, 2002 Aug 01. |
Review/Other-Dx |
135 patients |
To determine the clinical bronchiolitis obliterans in workers at a microwave-popcorn plant. |
Of the 135 current workers at the plant, 117 (87 percent) completed the questionnaire. These 117 workers had 2.6 times the expected rates of chronic cough and shortness of breath, according to comparisons with the national data, and twice the expected rates of physician-diagnosed asthma and chronic bronchitis. Overall, the workers had 3.3 times the expected rate of airway obstruction; those who had never smoked had 10.8 times the expected rate. Workers directly involved in the production of microwave popcorn had higher rates of shortness of breath on exertion and skin problems that had developed since they started work than workers in other parts of the plant. There was a strong relation between the quartile of estimated cumulative exposure to diacetyl and the frequency and extent of airway obstruction |
4 |
| 32. Verma H, Nicholson AG, Kerr KM, et al. Alveolar proteinosis with hypersensitivity pneumonitis: a new clinical phenotype. Respirology. 15(8):1197-202, 2010 Nov. |
Review/Other-Dx |
5 patients |
To report the features of five patients with concurrent histopathological features of pulmonary alveolar proteinosis (PAP) and hypersensitivity pneumonitis (HP) and their high-resolution CT (HRCT) appearances |
Five patients had histopathological features of HP and PAP but had varied HRCT appearances. All had imaging features of PAP to a varying degree with two patients also showing characteristics of HP but three patients had ill-defined thickened interlobular septa, not typical of either disease. |
4 |
| 33. Sharma BB, Singh S, Singh V. Hypersensitivity pneumonitis: the dug-well lung. Allergy Asthma Proc. 34(6):e59-64, 2013 Nov-Dec. |
Review/Other-Dx |
5 patients |
To examine a group of patients with HP due to a unique mechanism of environmental exposure. |
No results stated in the abstract |
4 |
| 34. Pereira Faria H, de Souza Veiga A, Coutinho Teixeira L, et al. Talcosis in soapstone artisans: high-resolution CT findings in 12 patients. Clinical Radiology. 69(3):e136-9, 2014 Mar. |
Review/Other-Dx |
12 patients |
To describe the high-resolution computed tomography (HRCT) features of pneumoconiosis observed in soapstone artisans |
All patients presented with interlobular septal thickening. Small centrilobular nodules (75%) and ground-glass opacities (67%) were also common findings. The distributions of abnormalities were predominantly diffuse. No pleural abnormality was found |
4 |
| 35. Kahkouee S, Pourghorban R, Bitarafan M, Najafizadeh K, Makki SS. Imaging Findings of Isolated Bronchial Anthracofibrosis: A Computed Tomography Analysis of Patients With Bronchoscopic and Histologic Confirmation. Arch Bronconeumol. 51(7):322-7, 2015 Jul. |
Review/Other-Dx |
58 patients |
To evaluate the chest computed tomography (CT) findings of patients with isolated bronchial anthracofibrosis confirmed by bronchoscopy and histopathology |
Central peribronchial soft tissue thickening (n=37, 63.8%) causing bronchial narrowing (n=37, 63.8%) or obstruction (n=11, 19%) was identified as an important finding on imaging. Multiple bronchial stenoses with concurrent involvement of 2, 3, and 5 bronchi were seen in 12 (21%), 9 (15%), and 2 (3.4%) patients, respectively. Segmental atelectasis and lobar or multilobar collapse were detected. These findings mostly occurred in the right lung, predominantly in the right middle lobe. Mosaic attenuation patterns, scattered parenchymal nodules, nodular patterns, and calcified or non-calcified lymph nodes were also observed. |
4 |
| 36. Lai PS, Hang JQ, Zhang FY, et al. Imaging Phenotype of Occupational Endotoxin-Related Lung Function Decline. Environ Health Perspect. 124(9):1436-42, 2016 09. |
Observational-Dx |
464 patients |
To identify the relative contributions of smoking and occupational endotoxin exposure to parenchymal and airway remodeling as defined by quantitative computed tomography (CT). |
Significant differences in all CT measures were noted across exposure groups. Occupational endotoxin exposure was associated with a decrease (-1.3%) in percent emphysema (LAAI-950), a 3.3-Hounsfield unit increase in 15th percentile density, an 18.1-g increase in lung mass, and a 2.3% increase in wall area percent. Current but not former smoking was associated with a similar CT phenotype. Changes in LAAI-950 were highly correlated with 15th percentile density (correlation -1.0). Lung mass was the only measure associated with forced expiratory volume in 1 sec (FEV1) decline, with each 10-g increase in lung mass associated with an additional loss (-6.1 mL) of FEV1 (p = 0.001) between 1981 and 2011. |
2 |
| 37. Kramer MR, Blanc PD, Fireman E, et al. Artificial stone silicosis [corrected]: disease resurgence among artificial stone workers.[Erratum appears in Chest. 2012 Oct;142(4):1080]. Chest. 142(2):419-424, 2012 Aug. |
Observational-Dx |
25 patients |
To determine the artificial stone silicosis: disease resurgence among artificial stone workers. |
During the 14-year study period, 25 patients with silicosis were referred for evaluation, including 10 patients who went on to undergo LTX. All patients were exposed by dry cutting a relatively new, artificial, decorative stone product with high crystalline silica content used primarily for kitchen countertops and bathroom fixtures. The patients had moderate-to-severe restrictive lung disease. Two patients developed progressive massive fibrosis; none manifested acute silicosis (silicoproteinosis). Three patients died during follow-up, without LTX. Based on the ISHLT registry incidence, 0.68 silicosis cases would have been expected instead of the 10 observed (incidence ratio, 14.6; 95% CI, 7.02-26.8). |
2 |
| 38. Hoy RF, Baird T, Hammerschlag G, et al. Artificial stone-associated silicosis: a rapidly emerging occupational lung disease. Occup Environ Med. 75(1):3-5, 2018 Jan. |
Review/Other-Dx |
7 patients |
To report the characteristics of a clinical series of Australian workers with artificial stone-associated silicosis. |
Seven male patients were identified with a median age of 44 years (range 26-61). All were employed in small kitchen and bathroom benchtop fabrication businesses with an average of eight employees (range 2-20). All workplaces primarily used artificial stone, and dust control measures were poor. All patients were involved in dry cutting artificial stone. The median duration of exposure prior to symptoms was 7?years (range 4-10). Six patients demonstrated radiological features of progressive massive fibrosis. These individuals followed up over a median follow-up period of 16 months (IQR 21 months) demonstrated rapid decline in prebronchodilator forced expiratory volume in 1?s of 386?mL/year (SD 204?mL) and forced vital capacity of 448?mL/year (SD 312?mL). |
4 |
| 39. Laney AS, Blackley DJ, Halldin CN. Radiographic disease progression in contemporary US coal miners with progressive massive fibrosis. Occup Environ Med. 74(7):517-520, 2017 Jul. |
Observational-Dx |
192 patients |
To examine radiographic progression in Coal Workers' Health Surveillance Program (CWHSP) participants. |
A total of 192 miners with a PMF determination contributed at least one additional radiograph (total count: 2-10). Mean age at first radiograph was 28.8 years, 162 (84%) worked in Kentucky, Virginia or West Virginia and 169 (88%) worked exclusively underground. A total of 163 (85%) miners had a normal initial radiograph. Mean time from most recent normal radiograph to one with a PMF determination was 20.7 years (range: 1-43) and 27 (17%) progressed to PMF in less than 10 years. |
2 |
| 40. Halldin CN, Petsonk EL, Laney AS. Validation of the international labour office digitized standard images for recognition and classification of radiographs of pneumoconiosis. Acad Radiol. 21(3):305-11, 2014 Mar. |
Observational-Dx |
172 patients |
To compare the results of classifications of digital chest images performed using the new ILO 2011 digitized standard images to classification approaches used in the past |
Agreement between classifications of FSR and digital radiography was identical, using a standard image set (either DRILO2011-D or DRRES). The overall weighted ? value was 0.58. Some specific differences in the results were seen and noted. However, intrareader variability in this study was similar to the published values and did not appear to be affected by the use of the new ILO 2011 digitized standard images. |
2 |
| 41. Dogan DO, Berk S, Gumus C, Ozdemir AK, Akkurt I. A longitudinal study on lung disease in dental technicians: what has changed after seven years?. Int J Occup Med Environ Health. 26(5):693-701, 2013 Oct. |
Observational-Dx |
19 dental technicians |
A 7-year follow-up study to determine respiratory changes in dental technicians |
In 2012, 19 out of the 36 technicians continued to work in the same place, so we were able to evaluate their findings. The prevalenceof respiratory symptoms in dental technician was as follows: dyspnea 7 (37%), cough 6 (32%), and phlegm 5 (26%).According to ILO classifications in 2005, among the 36 technicians, 5 (13.8%) had pneumoconiosis. At the end of 7 years,there were 9 pneumoconiosis cases among the 19 remaining technicians (47%). Thus, there was a statistically significantprogression on the profusion of the radiologic findings (p < 0.005). Also there was a significant worsening on spirometricfindings (p < 0.05). |
2 |
| 42. Tsao YC, Liu SH, Tzeng IS, Hsieh TH, Chen JY, Luo JJ. Do sanitary ceramic workers have a worse presentation of chest radiographs or pulmonary function tests than other ceramic workers?. J Formos Med Assoc. 116(3):139-144, 2017 Mar. |
Observational-Dx |
221 patients |
To describe and compare the clinical characteristics and silicosis-associated exposure history at work among workers from several types of ceramic production facilities in Taiwan. |
As compared to other ceramic workers, sanitary ceramic workers had a worse X-ray type (p=0.044), more advanced age (p < 0.001), longer working duration (p=0.029), and a higher proportion of starting the first relevant job prior to the year 1975 (p=0.003). However, after adjusting for age, work duration, and an initial occupational exposure prior to 1975, sanitary ceramic workers showed a comparable risk for worse X-ray findings to other ceramic workers (adjusted odds ratio=1.18, p=0.704). Results of multivariable regression models on individual lung function parameter also suggested comparably impaired lung function tests between sanitary and other ceramic workers (p > 0.05). |
3 |
| 43. Miller A, Warshaw R, Nezamis J. Diffusing capacity and forced vital capacity in 5,003 asbestos-exposed workers: relationships to interstitial fibrosis (ILO profusion score) and pleural thickening. Am J Ind Med. 56(12):1383-93, 2013 Dec. |
Observational-Dx |
5003 workers |
To describe the relationships between radiographic grading of interstitial and pleural fibrosis and a key test of pulmonary function, the diffusingcapacity, which measures gas exchange and has rarely been assessed in large groups, and to confirm the relationship to an independent test of pulmonary function, the vital capacity, which measures a mechanical property of the lungs. |
Both diffusing capacity and vital capacity were negatively correlated with profusion score over the full spectrum of radiographic severity. ILO profusion scores 0/1 (conventionally classified as normal) and 1/0 (conventionally classified as abnormal) were associated with similar diffusing capacity and vital capacity values. The highest profusion scores were associated with a greater proportionate decrease in diffusing capacity than in FVC. Both tests showed an effect of pleural fibrosis. |
2 |
| 44. International Labour Office. Guidelines for the use of the ILO international classification of radiographs of pneumoconioses. Revised edition 2011. ed. Geneva: International Labour Office; 2011. |
Review/Other-Dx |
N/A |
Guidelines for the use of ILO international classification of radiographs of pneumoconioses. |
N/A |
4 |
| 45. Lee WJ, Choi BS. Reliability and validity of soft copy images based on flat-panel detector in pneumoconiosis classification: comparison with the analog radiographs. Acad Radiol. 20(6):746-51, 2013 Jun. |
Observational-Dx |
349 subjects |
To evaluate the reliability and validity of soft copy images based on flat-panel detector of digital radiography (DR-FPD soft copy images) compared to analog radiographs (ARs) in pneumoconiosis classification and diagnosis. |
In small opacity, overall interreader agreement of DR-FPD soft copy images was significantly higher than that of ARs, but it wasnot significantly different in large opacity and costophrenic angle obliteration. In small opacity, agreement of DR-FPD soft copy images withCR was significantly higher than that of ARs with CR. It was also higher than that of ARs with CR in pleural plaque and thickening. Receiveroperating characteristic areas were not different significantly between DR-FPD soft copy images and ARs. |
3 |
| 46. Sen A, Lee SY, Gillespie BW, et al. Comparing film and digital radiographs for reliability of pneumoconiosis classifications: a modeling approach. Acad Radiol. 17(4):511-9, 2010 Apr. |
Observational-Dx |
107 subjects, 318 images, 6 readers |
To compare the inter-reader and intra-reader agreement of ILO classi?cations for pneumoconiosis across image formats |
There were few signi?cant differences in the inter-reader and intra-reader agreemen across formats. For parenchymal abnormalities, inter-reader and intra-reader kappa values ranged from 0.536 to 0.646, and 0.65 to 0.77, respectively. In the covariate-adjusted analysis ?lm-screen radiography was generally associated with a numerically greater reliability (ie, higher kappa values) than the other image formats, although differences were rarely statistically signi?cant. |
2 |
| 47. Laney AS, Petsonk EL, Attfield MD. Intramodality and intermodality comparisons of storage phosphor computed radiography and conventional film-screen radiography in the recognition of small pneumoconiotic opacities. Chest. 140(6):1574-1580, 2011 Dec. |
Observational-Dx |
172 underground coal miners |
To explore several previously observed intermodality differences (with respect to the designation of small opacity shapeand size, and the proportion of miners demonstrating high opacity profusion) and extended earlier comparisonsof reader variability in the classification of pneumoconiosis between the two radiographic modalities. |
More CRs were classified as “good” quality compared with FSRs (prevalence ratio [PR], 1.5; 95% CI, 1.4-1.6; P , .001). B readers showed good overall agreement on scoring small opacity profusion using CRs vs FSRs (weighted k , 0.58; 95% CI, 0.54-0.62). Significantly more irregular opacities (compared with rounded) were classified using CR images compared with FSR (PR, 1.3; 95% CI, 1.1-1.6; P = .01). Similarly, the smallest sized opacities (width < 1.5 mm, p and s type) were reported more frequently using CR vs FSR images (PR, 1.3; 95% CI, 1.1-1.5; P < .001). Interreader and intrareader agreement was lower with respect to the classification of shape and size than for small opacity profusion. Overall, interreader and intrareader variability did not differ significantly using CR vs FSR. |
2 |
| 48. Carrillo MC, Alturkistany S, Roberts H, et al. Low-dose computed tomography (LDCT) in workers previously exposed to asbestos: detection of parenchymal lung disease. J Comput Assist Tomogr. 37(4):626-30, 2013 Jul-Aug. |
Observational-Dx |
315 patients |
To evaluate the lungs of asymptomatic asbestos-exposed workers who were screened for lung cancer and mesothelioma using low-dose computed tomography (LDCT) for parenchymal abnormalities. |
Three hundred fifteen subjects were studied. The mean age was 61.7 years, and the mean exposure to asbestos was 26.9 years. One hundred seventy-five (56%) participants had absence of parenchymal findings with a mean age of 58.7 years, mean exposure of 24.6 years, and a mean smoking pack years of 19. One hundred forty subjects (44%) had parenchymal findings (138 men and 2 women) with a mean age of 65.3 years, mean exposure of 29.73 years, and a mean smoking pack years of 21.5 years. Participants who had parenchymal manifestations were more likely to be older and have longer exposure to asbestos compared to participants who had no relevant parenchymal findings. There was no statistical difference in the mean smoking pack years between the groups with and without parenchymal findings. |
2 |
| 49. Tamura T, Suganuma N, Hering KG, et al. Relationships (I) of International Classification of High-resolution Computed Tomography for Occupational and Environmental Respiratory Diseases with the ILO International Classification of Radiographs of Pneumoconioses for parenchymal abnormalities. Industrial Health. 53(3):260-70, 2015. |
Observational-Dx |
74 patients |
To establish a correlation between readings of HRCT (according to the ICOERD) and those of chest radiography (CXR) pneumoconiotic parenchymal opacities (according to the International Labor Organization Classification/International Classification of Radiographs of Pneumoconioses [ILO/ICRP]). |
No results stated in the abstract. |
2 |
| 50. Lavelle LP, Brady D, McEvoy S, et al. Pulmonary fibrosis: tissue characterization using late-enhanced MRI compared with unenhanced anatomic high-resolution CT. Diagn Interv Radiol. 23(2):106-111, 2017 Mar-Apr. |
Observational-Dx |
20 patients |
To evaluate anatomic chest computed tomography (CT) with tissue characterization late gadolinium-enhanced magnetic resonance imaging (MRI) in the evaluation of pulmonary fibrosis (PF). |
No control patient exhibited contrast enhancement on lung late-enhanced MRI. All IPF patients were identified with late-enhanced MRI. Mean signal intensity of the late-enhanced fibrotic lung was 31.8±10.6 vs. 10.5±1.6 for normal lung regions, P < 0.001, resulting in a percent elevation in signal intensity from PF of 204.8%±90.6 compared with the signal intensity of normal lung. The mean contrast-to-noise ratio was 22.8±10.7. Late-enhanced MRI correlated significantly with chest CT for the extent of PF (R=0.78, P = 0.001) but not for reticulation, honeycombing, or coarseness of reticulation or honeycombing. |
2 |
| 51. Pinal-Fernandez I, Pineda-Sanchez V, Pallisa-Nunez E, et al. Fast 1.5 T chest MRI for the assessment of interstitial lung disease extent secondary to systemic sclerosis. Clin Rheumatol. 35(9):2339-45, 2016 Sep. |
Observational-Dx |
18 patients |
To evaluate the utility of magnetic resonance imaging (MRI) to assess interstitial lung disease (ILD) extent in patients with systemic sclerosis (SSc). Patients with SSc and varying degrees of ILD with a high-resolution computed tomography (HRCT), pulmonary function tests (PFTs), and a chest MRI containing an ultrafast SE sequence performed less than 1 year apart were included in the study |
No results stated in the abstract. |
2 |
| 52. Mirsadraee S, Tse M, Kershaw L, et al. T1 characteristics of interstitial pulmonary fibrosis on 3T MRI-a predictor of early interstitial change?. Quant. imaging med. surg.. 6(1):42-9, 2016 Feb. |
Observational-Dx |
10 Patients |
To evaluate T1 characteristics in the radiologically diseased lung parenchyma in IPF patient compared to apparently normal parenchyma in both interstitial lung disease (ILD) patients and healthy volunteers and to investigate the feasibility of the technique in prediction of early fibrotic lung changes that may not be visible on CT. |
Fibrotic lung had a higher pre-contrast T1 than either morphologically normal lung in ILD patients or control lung (P=0.02) in healthy volunteers (1309±123, 1069±71, and 1011±172 ms, respectively). Morphologically normal lung T1 and control lung T1 were not significantly different pre-contrast, however, at 10 min after administration of Gadolinium, control lung had a significantly shorter T1 than either fibrotic or morphologically normal lung (494±34, 670±63, and 619±41 ms, respectively; P=0.001). T1 for fibrotic lung continued to decrease until 20 min after contrast agent administration (P=0.0001), whereas morphologically normal lung T1 did not significantly change after 10 min (P>0.3). This indicates delayed uptake of contrast agent in the fibrotic lung compared with morphologically normal lung. |
2 |
| 53. Yi CA, Lee KS, Han J, Chung MP, Chung MJ, Shin KM. 3-T MRI for differentiating inflammation- and fibrosis-predominant lesions of usual and nonspecific interstitial pneumonia: comparison study with pathologic correlation. AJR Am J Roentgenol. 2008; 190(4):878-885. |
Observational-Dx |
26 patients |
To evaluate the utility of 3T MRI of the lung for differentiating inflammation- and fibrosis-predominant lesions in the usual and nonspecific types of interstitial pneumonia. |
Inflammation-predominant specimens were obtained from 31% (17/54) of the biopsy sites. Inflammation-predominant biopsy sites had an early enhancement pattern (82%, 14/17 sites, P<0.001) on dynamic studies and high signal intensity (53%, 9/17 sites, P=0.001) on T2-weighted triple-inversion black blood fast-spin echo images. Multiphase dynamic enhancement studies with a turbo field-echo sequence and T2-weighted triple-inversion black blood fast-spin echo images on 3-T MRI appear to be useful for differentiating inflammation- and fibrosis-predominant lesions. |
2 |
| 54. Fujimoto N, Kato K, Usami I, et al. Asbestos-related diffuse pleural thickening. Respiration. 88(4):277-84, 2014. |
Observational-Dx |
106 patients |
To clarify the association between radiological findings of diffuse pleural thickening (DPT) and respiratory function. |
There were 106 DPT patients between 2005 and 2010 [i.e. 103 men (97.2%) and 3 women (2.8%)]. The median age at diagnosis was 69 years (range 46–88). Patient occupations related to asbestos exposure included: asbestos product manufacturing (n = 17); the shipbuilding industry (n = 14); the construction industry (n = 13); heat insulation work (n = 12); plumbing, asbestos spraying, and electrical work (n = 7 each), and transportation and demolition work (n = 4 each). The median duration of asbestos exposure was 25 years (range 2–54), and the median latency period before the onset of DPT was 46 years (range 25–66). Involvement of the costophrenic angle (CPA) was also negatively correlated with the percent vital capacity (%VC; r = –0.448, p < 0.01). Pleural thickness and the craniocaudal and horizontal extension of pleural thickening, as determined by chest computed tomography (CT), were also negatively correlated with %VC (r = –0.226, p < 0.05; r = –0.409, p < 0.01, and r = –0.408, p < 0.01, respectively). |
3 |
| 55. Ergun D, Ergun R, Evcik E, Nadir Ozis T, Akkurt I. The relation between the extent of radiological findings and respiratory functions in pneumoconiosis cases of dental technicians who are working in Ankara. Tuberkuloz ve Toraks. 64(2):127-36, 2016 Jun. |
Observational-Dx |
440 dental technicians |
To evaluate the relationship between radiological scores (chest X-ray/HRCT) indicating extent of pulmonary involvement and the severity of functional findings in dental technicians. |
Mean age of the study population was 34.7 ± 8.5 and mean duration of work was 16.5 ± 7.9 years. The prevalance of Dental technicians’ pneumoconiosis (DTP) was 11.1%. The most common opacity in HRCT was round opacity with a rate of 89.7%. The rate of large opacity was %14.3. There was positive correlation between ILO score and HRCT score. Negative correlation was found between ILO and HRCT scores and all pulmonary function tests (except for FEV1/FVC), while no relation was found with age, overall duration of exposure, smoking and the age ofwork onset. In Multiple regression analysis, the extent of pulmonary involvement (HRCT scores) was found to be an independent predictor of functional impairment. Functional parameter reflecting the extent of pulmonary involvement most accurately was (FEV1%). |
2 |
| 56. Tiwari RR.. Agreement between chest radiography and high-resolution computed tomography in diagnosing dust-related interstitial lung fibrosis. Toxicol Ind Health. 31(3):235-8, 2015 Mar. |
Observational-Dx |
22 workers |
To compare the relative efficacy of chest radiography by conventional method and high-resolution computed tomography (HRCT) in evaluating interstitial lung fibrosis (ILF). |
In the six subjects who had findings suggestive of ILF on HRCT, four had normal chest x-ray (CXR) while one each has been diagnosedas having tuberculosis and ILF on CXR. The agreement analysis between HRCT and CXR suggests that therewas a poor agreement between HRCT and CXR (kappa = 0.34). |
3 |
| 57. Larson TC, Franzblau A, Lewin M, Goodman AB, Antao VC. Impact of body mass index on the detection of radiographic localized pleural thickening. Acad Radiol. 21(1):3-10, 2014 Jan. |
Observational-Dx |
200 subjects |
To examine the influence of body mass index (BMI) on the performance of radiograph readers when classifying localized pleural thickening (LPT) and to model the risk of false test results with varying BMI. |
The proportion of false-positive readings correlated with BMI. While controlling for covariates, regression modeling showed the probability of a false-positive result increased with increasing BMI category, younger age, not having pleural calcification, and among subjects not reporting occupational or household contact asbestos exposure. |
2 |
| 58. Xing J, Huang X, Yang L, Liu Y, Zhang H, Chen W. Comparison of high-resolution computerized tomography with film-screen radiography for the evaluation of opacity and the recognition of coal workers' pneumoconiosis. J Occup Health. 56(4):301-8, 2014. |
Observational-Dx |
96 coal miners with radiographic evidence of CWP, 67 coal miners without CWP and 37 healthy controls |
To compare high-resolution computerized tomography (HRCT) and film-screen radiography (FSR) for recognition of the profusion of small opacities, opacity shape and opacity coalescence in coal miners with or without radiographic evidence of coal workers’ pneumoconiosis (CWP) and evaluate the possible role of HRCT in CWP diagnosis. |
The overall agreement for CWP evaluation was good (crude agreement rate=87.1%, ?=0.72, 95% Pneumoconiosis CI: 0.62-0.83) between FSR and HRCT in all coal miners. The sensitivity of HRCT for CWP diagnosis was 96.9% (93/96). We observed that 18 of the 67 (26.9%) miners negative for CWP by FSR were classified as category 1 by HRCT according to the lung parenchyma profusion category system reported by Bérgin et al. The difference in the profusion scores between CWP subjects and healthy controls for HRCT scans were statistically significantly higher than those for FSR. |
2 |
| 59. Laurent F, Paris C, Ferretti GR, et al. Inter-reader agreement in HRCT detection of pleural plaques and asbestosis in participants with previous occupational exposure to asbestos. Occup Environ Med. 71(12):865-70, 2014 Dec. |
Observational-Dx |
5511 participants |
To investigate inter-reader agreement for the detection of pleural and parenchymal abnormalities using CT in a large cross-sectional study comprising information on individual cumulative exposure to asbestos. |
?-Weighted coefficients between trained experts ranged from 0.28 to 0.52 (fair to good), 0.59 to 0.86 (good to excellent) and 0.11 to 0.66 (poor to good) for the diagnosis of asbestosis, pleural plaques and fibrosis of the visceral pleura, respectively. ?-Weighted coefficients between results of routine practice and final diagnosis after expert reading were 0.13 (poor), 0.53 (moderate) and 0.11 (poor) for the diagnosis of asbestosis, pleural plaques and fibrosis of the visceral pleura, respectively. |
1 |
| 60. Perez-Alonso A, Cordoba-Dona JA, Millares-Lorenzo JL, Figueroa-Murillo E, Garcia-Vadillo C, Romero-Morillos J. Outbreak of silicosis in Spanish quartz conglomerate workers. Int J Occup Environ Health. 20(1):26-32, 2014 Jan-Mar. |
Review/Other-Dx |
46 men |
To describe the epidemiological and clinical characteristics of an outbreak of occupational silicosis and the associated working conditions. |
Silicosis was diagnosed in 46 men with a median age of 33 years and a median of 11 years working in the manufacturing of countertops. Of these cases, 91.3% were diagnosed with simple chronic silicosis, with an abnormal high-resolution computerized tomography (HRCT) scan. One patient died during the study period. Employer non-compliance in prevention and control measures was frequently reported, as were environmental and individual protection failures. |
4 |
| 61. Kahraman H, Koksal N, Cinkara M, Ozkan F, Sucakli MH, Ekerbicer H. Pneumoconiosis in dental technicians: HRCT and pulmonary function findings. Occupational Medicine (Oxford). 64(6):442-7, 2014 Sep. |
Observational-Dx |
76 participants |
To document pulmonary function and prevalence of pneumoconiosis in dental prosthetic technicians (DPTs). |
There were 76 participants and pneumoconiosis was diagnosed in 46%. The most commonly seen radiological finding was round opacities, present in 38%. Agreement among HRCT readers was moderate to good. As defined by HRCT, emphysema was diagnosed more often in those with a longer occupational history or a history of smoking, and low carbon monoxide diffusion capacity (DLCO), but not in those with pneumoconiosis. Forced expiratory rate and DLCO were significantly lower in those who had worked 16 years or more (all P < 0.05). DLCO values were significantly lower in technicians with emphysema and in current smokers (all P < 0.01). Round opacities were also present in a substantial proportion of DPTs who had 15 years or less exposure. Because HRCT is able to detect radiological changes of occupational lung disease very early, the prevalence of pneumoconiosis in our participants was quite high. |
1 |
| 62. Costa C, Ascenti G, Scribano E, et al. CT patterns of pleuro-pulmonary damage caused by inhalation of pumice as a model of pneumoconiosis from non-fibrous amorphous silicates. Radiologia Medica. 121(1):19-26, 2016 Jan. |
Observational-Dx |
36 workers |
To correlate the radiological features of pleuro-pulmonary damage caused by inhalation of pumice (an extrusive volcanic rock classified as a non-fibrous, amorphous, complex silicate) with exposure conditions. |
Among the 36 workers examined, we identified four CT patterns which resulted to be dependent on exposure duration and intensity, FVC, FEV1 and FEF25–75, but not on cigarette smoking. The most common symptoms reported by clinical examination were dyspnoea, cough and asthenia. In no case it was proven an evolution of CT findings during follow-up for 10 years. |
3 |
| 63. Siribaddana AD, Wickramasekera K, Palipana WM, et al. A study on silicosis among employees of a silica processing factory in the Central Province of Sri Lanka. Ceylon Med J. 61(1):6-10, 2016 Mar. |
Review/Other-Dx |
250 factory employees |
To assess the prevalence of silicosis among workers exposed to silica dust, and to describe the disease pattern of the affected. |
Of the 250 employees 25 (10%) had respiratory symptoms. Chest radiographs of 14 workers (5.6%) showed abnormalities diagnostic of silicosis. The mean age of the affected workers was 29 years. One worker had radiological changes suggestive of progressive massive fibrosis. Of 14 patients, 13 had duration of exposure less than 10 years suggestive of accelerated silicosis. Among the 14 workers diagnosed with silicosis five (35.7%) had Mantoux induration of more than 10 mm suggestive of latent tuberculesis. |
4 |
| 64. Arakawa H, Kishimoto T, Ashizawa K, et al. Asbestosis and other pulmonary fibrosis in asbestos-exposed workers: high-resolution CT features with pathological correlations. Eur Radiol. 26(5):1485-92, 2016 May. |
Observational-Dx |
33 workers |
To identify distinguishing CT features of pathologically diagnosed asbestosis, and correlate diagnostic confidence with asbestos body burden. |
Pathologically, 15 cases were diagnosed as asbestosis and 18 cases with various lung fibroses other than asbestosis. On CT, only the score of the subpleural curvilinear lines was significantly higher in asbestosis (p=0.03). Accuracy of CT diagnosis of asbestosis with a high confidence ranged from 0.73 to 0.79. Asbestos body count positively correlated with CT likelihood of asbestosis (r=0.503, p=0.003), and with the confidence level of pathological diagnosis (r=0.637, p<0.001). |
2 |
| 65. Akira M, Yamamoto S, Inoue Y, Sakatani M. High-resolution CT of asbestosis and idiopathic pulmonary fibrosis. AJR Am J Roentgenol. 181(1):163-9, 2003 Jul. |
Observational-Dx |
80 patients with asbestosis and 80 patients with idiopathic pulmonary fibrosis |
To study high-resolution CT of asbestosis and idiopathic pulmonary ?brosis and determine whether differences—other than the frequency of associated pleural changes—could be discerned between the two diseases. |
Subpleural dotlike or branching opacities (65/80), subpleural curvilinear lines (55/80), mosaic perfusion (39/80), and parenchymal bands (38/80) were more common in patients with asbestosis ( p < 0.0001). Visible intralobular bronchioles (62/80), bronchiolectasis within ?brotic consolidations (47/80), and honeycombing (61/80) were more common in patients with idiopathic pulmonary ?brosis ( p < 0.0001). The frequencies of interlobular septal thickening, ground-glass opacities, ?brotic consolidation, and emphysema were similar in both groups. Parenchymal bands and ?brotic consolidation were more commonly seen ( p <0. 05) in patients with asbestosis associated with pleural disease ( n = 66) than in patients with asbestosis without pleural disease ( n = 14). Also, statistically signi?cant differences were noted between high-resolution CT ?ndings of patients with asbestosis without pleural disease and those of patients with idiopathic pulmonary ?brosis, except for parenchymal bands |
2 |
| 66. Jeong YJ, Lee KS, Chung MP, Han J, Johkoh T, Ichikado K. Chronic hypersensitivity pneumonitis and pulmonary sarcoidosis: differentiation from usual interstitial pneumonia using high-resolution computed tomography. [Review]. Semin Ultrasound CT MR. 35(1):47-58, 2014 Feb. |
Review/Other-Dx |
N/A |
To observe the distinction of chronic hypersensitivity pneumonitis (HP) or advanced-stage sarcoidosis from idiopathic pulmonary fibrosis or usual interstitial pneumonia. |
No results stated in abstract. |
4 |
| 67. de Castro MC, Ferreira AS, Irion KL, et al. CT quantification of large opacities and emphysema in silicosis: correlations among clinical, functional, and radiological parameters. Lung. 192(4):543-51, 2014 Aug. |
Observational-Dx |
23 patients |
To assess correlations between the lung function (measured by pulmonary function tests (PFTs)) and anatomical changes (measured by CT densitovolumetry, silicotic masses, and emphysema) in patients with PMF and use the correlations to understand the potential and limitations of both methods for assessing patients with complicated silicosis. |
Significant correlations were observed between the EV and the forced vital capacity (r = 0.41, p = 0.04), TLC (r = 0.44, p = 0.03), and residual volume (RV) (r = 0.49, p = 0.01). A correlation also was observed between the LD% and RV (r = 0.43, p = 0.03) and between the LD and RV (r = 0.47, p = 0.02). |
2 |
| 68. Nunes H, Schubel K, Piver D, et al. Nonspecific interstitial pneumonia: survival is influenced by the underlying cause. European Respiratory Journal. 45(3):746-55, 2015 Mar. |
Observational-Dx |
127 patients |
to compare the prognosis of NSIP patients stratified according to the underlyingcause (idiopathic, UCTD, CTDs and cHP) in terms of survival, response to therapy and long-termfunctional outcome. |
This retrospective study included 127 biopsy-proven NSIP patients (65 women, mean±SD age55±12 years). Survivals were estimated using a Kaplan–Meier curve and compared using the log-rank test.Multivariate analyses were based on a Cox model.15 (11.8%) patients had cHP, 29 (22.8%) had CTD, 32 (25.2%) satisfied the Kinder criteria for UCTDand 51 (40.1%) had idiopathic NSIP. At the end of follow-up (mean±SD 64±54 months), a difference insurvival was observed between aetiological groups (p=0.002). Survival was better for UCTD than foridiopathic NSIP (p=0.020) and similar to that observed for CTD. cHP survival tended to be poorer thanthat of idiopathic NSIP (p=0.087) and was an independent predictor of mortality (hazard ratio 2.17, 95%CI 1.05–4.47; p=0.035).NSIP outcome is influenced by its cause. cHP exhibits the highest mortality. UCTD does not differ fromCTD supporting the concept of autoimmune NSIP, with a prognosis that is better than that of idiopathic NSIP. |
3 |
| 69. Soumagne T, Chardon ML, Dournes G, et al. Emphysema in active farmer's lung disease. PLoS ONE. 12(6):e0178263, 2017. |
Observational-Dx |
33 patients |
To evaluate the current prevalence of emphysema in active FL, to describe the radiological and functional features of emphysema in active FL, and to identify risk factors associated with emphysema in this population. |
Among 33 patients with active FL, the prevalence of emphysema in this series of incident active FL cases was higher (48.5%) than that of fibrosis (12%) and was not dependent on smoking habits. Most patients with emphysema did not have lung hyperinflation. The possible risk factors for emphysema in active FL were a longer duration of exposure to organic dusts, and at a higher level. |
2 |
| 70. Akira M, Morinaga K. The comparison of high-resolution computed tomography findings in asbestosis and idiopathic pulmonary fibrosis. Am J Ind Med. 59(4):301-6, 2016 Apr. |
Observational-Dx |
96 patients with asbestosis and 65 patients with IPF |
To determine whether the HRCT findings are useful to differentiate asbestosis from idiopathic pulmonary fibrosis (IPF). |
There was a significant difference between IPF and asbestosis in pleural changes. In addition, there were significant differences between IPF and asbestosis in several parenchymal abnormalities on CT, especially in the less advanced stage of both diseases. On multivariate analysis, HRCT features that distinguished asbestosis from IPF were subpleural lines at a distance of less than 5mm from the inner chest wall, subpleural dots and parenchymal bands. |
3 |
| 71. Schikowsky C, Felten MK, Eisenhawer C, Das M, Kraus T. Lung function not affected by asbestos exposure in workers with normal Computed Tomography scan. Am J Ind Med. 60(5):422-431, 2017 May. |
Observational-Dx |
207 patients |
To analyze the associations between well-known asbestos-related risk factors, such as individual cumulative asbestos exposure, and key lung function parameters in formerly asbestos-exposed power industry worker |
The lung function parameters of FVC, FEV1, DLCO/VA, and airway resistance were significantly associated with the burden of smoking, BMI and years since end of exposure (only DLCO/VA). However, they were not affected by factors directly related to amount (eg, cumulative exposure) or duration of asbestos exposure. |
2 |
| 72. Tamura T, Suganuma N, Hering KG, et al. Relationships (II) of International Classification of High-resolution Computed Tomography for Occupational and Environmental Respiratory Diseases with ventilatory functions indices for parenchymal abnormalities. Industrial Health. 53(3):271-9, 2015. |
Observational-Dx |
35 patients and 27 controls |
To investigate the relationship between subject characteristics and parenchymal abnormalities according to The International Classification of High-Resolution Computed Tomography (HRCT) for Occupational and Environmental Respiratory Diseases (ICOERD), and the results of ventilatory function tests (VFT). |
High-resolution computed tomography showed that 11 patients had RO; 15 patients, IR; and 19 patients, EM. According to the multiple regressionmodel, age and height had significant associations with many indices ventilatory functions such as vital capacity, forced vital capacity, and forced expiratory volume in 1 s (FEV1). The EM summed grades on the upper, middle, and lower zones of the right and left lungs also had significant associations with FEV1 and the maximum mid-expiratory flow rate. |
2 |
| 73. Vehmas T, Oksa P. Chest HRCT signs predict deaths in long-term follow-up among asbestos exposed workers. Eur J Radiol. 83(10):1983-7, 2014 Oct. |
Observational-Dx |
663 patients |
To study associations between chest HRCT signs and subsequent deaths in long-term follow-up. |
The follow-up totalled 5271.9 person-years (mean 8.3 y/person, range .04-10.3). 119 deaths were reported. Irregular/linear opacities, honeycombing, emphysema, large opacities, visceral pleural abnormalities and bronchial wall thickening were all significantly related to all-cause deaths. Most of these signs were associated also with deaths from neoplasms and benign respiratory disease. Deaths from cardiovascular disease were predicted by emphysema and visceral pleural abnormalities. |
2 |
| 74. Terra-Filho M, Bagatin E, Nery LE, et al. Screening of miners and millers at decreasing levels of asbestos exposure: comparison of chest radiography and thin-section computed tomography. PLoS ONE. 10(3):e0118585, 2015. |
Observational-Dx |
1418 workers |
1. To compare the diagnostic performance of CRX and Thin-section CT in a large group of miners and millers who were separated in groups of decreasing asbestos exposure2. To investigate the incidence of interstitial and pleural abnormalities on CXR and Thin-section CT in a subgroup of subjects with no previous abnormalities on both methods.3. To assess whether individuals exposed to asbestos with and without interstitial and pleural changes have differences in spirometric variables. |
In all groups, CXR suggested more frequently interstitial abnormalities and less frequently pleural plaques than observed on Thin-section CT (p<0.050). The odds for asbestosis in groups of decreasing exposure diminished to greater extent at Thin-section CT than on CXR. Lung function was reduced in subjects who had pleural plaques evident only on Thinsection CT (p<0.050). In a longitudinal evaluation of 301 subjects without interstitial and pleural abnormalities on CXR and Thin-section CT in a previous evaluation, only Thin-section CT indicated that these ARA reduced as exposure decreased. |
2 |
| 75. Hekimoglu K, Sancak T, Tor M, Besir H, Kalaycioglu B, Gundogdu S. Fast MRI evaluation of pulmonary progressive massive fibrosis with VIBE and HASTE sequences: comparison with CT. Diagnostic & Interventional Radiology. 16(1):30-7, 2010 Mar. |
Observational-Dx |
22 PMF lesions from 20 coal workers |
To evaluate the diagnostic utility of volumetric interpolated breath-hold examination (VIBE) and half-Fourier-acquisition single-shot turbo spin-echo (HASTE) fast magnetic resonance imaging (MRI) sequences in the evaluation of pulmonary progressive massive fibrosis (PMF) in comparison with computed tomography (CT) imaging. |
There was almost perfect agreement among radiologists for lesion detection with kappa analysis. There was significant agreement between three MRI study groups and gold standard CT images. The authors found the best agreement values with contrast- enhanced VIBE images for lesion detection and image quality in comparison with CT imaging. Presence of artifact was also lowest with this protocol. |
1 |
| 76. Silva CI, Muller NL, Neder JA, et al. Asbestos-related disease: progression of parenchymal abnormalities on high-resolution CT. J Thorac Imaging. 2008;23(4):251-257. |
Review/Other-Dx |
52 male asbestos workers |
To evaluate the changes over time in the pattern and extent of parenchymal abnormalities in asbestos-exposed workers after cessation of exposure and to compare 3 proposed semiquantitative methods with a careful side-by-side comparison of the initial and the follow-up computed tomography (CT) images. |
There was no difference in the prevalence of the 2 most common parenchymal abnormalities (centrilobular small dotlike or branching opacities and interstitial lines) between the initial and follow-up CT scans. Honeycombing (20%) and traction bronchiectasis and bronchiolectasis (50%) were seen more commonly on the follow-up CT than on the initial examination (10% and 33%, respectively) (P=0.01). Increased extent of parenchymal abnormalities was evident on side-by-side comparison in 42 (81%) patients but resulted in an increase in score in at least 1 semiquantitative system in only 16 (31%) patients (all P>0.01, signed test). |
4 |
| 77. Johannson KA, Elicker BM, Vittinghoff E, et al. A diagnostic model for chronic hypersensitivity pneumonitis. Thorax. 71(10):951-4, 2016 Oct. |
Observational-Dx |
190 patients |
To develop a diagnostic model that allows for a highly specific diagnosis of chronic hypersensitivity pneumonitis using clinical and radiological variables alone. |
High-resolution CT scans were blindly scored for radiographic features (eg, ground-glass opacity, mosaic perfusion) as well as the radiologist’s diagnostic impression. Candidate models were developed then evaluated using clinical and radiographic variables and assessed by the cross-validated C-statistic. Forty-four chronic hypersensitivity pneumonitis and eighty other interstitial lung disease cases were identified. Two models were selected based on their statistical performance, clinical applicability and face validity. Key model variables included age, down feather and/or bird exposure, radiographic presence of ground-glass opacity and mosaic perfusion and moderate or high confidence in the radiographic impression of chronic hypersensitivity pneumonitis. Models were internally validated with good performance, and cut-off values were established that resulted in high specificity for a diagnosis of chronic hypersensitivity pneumonitis. |
2 |
| 78. Okamoto T, Miyazaki Y, Ogura T, et al. Nationwide epidemiological survey of chronic hypersensitivity pneumonitis in Japan. Respir Investig. 51(3):191-9, 2013 Sep. |
Review/Other-Dx |
222 cases and 22 hospitals |
To conduct a nationwide epidemiological survey of chronic hypersensitivity pneumonitis (HP) in Japan to determine better estimates of the frequency and clinical features of the disease. |
In total, 222 cases of chronic HP from 22 hospitals were studied. Disease subtypes included bird-related HP (n=134), summer-type HP (n=33), home-related HP (n=25), farmer's lung (n=4), isocyanate-induced HP (n=3), and other types (n=23). The median proportion of lymphocytes in bronchoalveolar lavage fluid was high (24.5%). The primary findings of computed tomography of the chest were ground-glass attenuation and interlobular septal thickening. Centrilobular fibrosis was the major pathological finding on examination of surgical lung biopsy specimens from 93 patients. The median survival time was 83 months. |
4 |
| 79. Paris C, Herin F, Reboux G, et al. Working with argan cake: a new etiology for hypersensitivity pneumonitis. BMC polm. med.. 15:18, 2015 Mar 06. |
Review/Other-Dx |
9 workers |
To conduct a systematic survey of all workers exposed under similar conditions in order to identify other possible cases of hypersensitivitypneumonitis (HP) and identify the antigen responsible. |
Six of the nine workers experienced flu-like symptoms within 8 hours after argan handling. After challenge,two subjects presented a significant decrease of DLCO and alveolitis with mild lymphocytosis, and one presentedground glass opacities. These two patients and another patient presented significant arcs to both granulates andnon-sterile powder. No reactivity was observed to sterile argan finished product, antigens derived from argancultures (various species of Bacillus) and Streptomyces marokkonensis (reported in the literature to contaminateargan roots). |
4 |
| 80. Miyazaki Y, Tateishi T, Akashi T, Ohtani Y, Inase N, Yoshizawa Y. Clinical predictors and histologic appearance of acute exacerbations in chronic hypersensitivity pneumonitis. Chest. 134(6):1265-70, 2008 Dec. |
Observational-Dx |
100 patients |
To evaluate the clinical features of the patients with Acute exacerbations (AEs) in those with chronic hypersensitivity pneumonitis (HP). |
AE developed in 14 patients during this observation period (AE group), whereas 86 patients remained stable (non-AE [NAE] group). The 2-year frequency of AE among patients with chronic BFL having usual interstitial pneumonia (UIP)-like lesions seen on surgical lung specimens was 11.5%. Patients with AE were more likely to be smokers (p = 0.003). In pulmonary function test results, the mean total lung capacity (TLC) and diffusing capacity of the lung for carbon monoxide (Dlco) were lower in patients with AEs (TLC: AE patients, 63.0 +/- 16.8%; NAE patients, 81.6 +/- 20.0%; Dlco: AE patients, 41.9 +/- 19.0%; NAE patients, 60.0 +/- 19.4%). The mean number of lymphocytes in BAL fluid were lower (AE patients, 13.7 +/- 7.5 lymphocytes; NAE patients, 37.2 +/- 29.7 lymphocytes), while the number of neutrophils were greater in AE patients (AE patients, 10.7 +/- 17.6 neutrophils; NAE patients, 3.6 +/- 4.4 neutrophils). Histologic and/or radiologic findings revealed that all AE patients had UIP-like lesions. Diffuse alveolar damage was observed in six cases, whereas organizing pneumonia superimposed on preexistent fibrotic lesions was observed in two cases. |
2 |
| 81. Walsh SL, Sverzellati N, Devaraj A, Wells AU, Hansell DM. Chronic hypersensitivity pneumonitis: high resolution computed tomography patterns and pulmonary function indices as prognostic determinants. Eur Radiol. 22(8):1672-9, 2012 Aug. |
Observational-Dx |
92 patients |
To investigate high resolution computed tomography (HRCT) and pulmonary function indices (PFTs) for determining prognosis in patients with chronic fibrotic hypersensitivity pneumonitis (CHP). |
There were forty two deaths during the study period. Increasing severity of traction bronchiectasis was the strongest predictor of mortality (HR 1.10, P < 0.001, 95%CI 1.04-1.16). Increasing global interstitial disease extent (HR 1.02, P = 0.02, 95%CI 1.00-1.03), microcystic honeycombing (HR 1.09, P = 0.019, 95%CI 1.01-1.17) and macrocystic honeycombing (HR 1.06, P < 0.01, 95%CI 1.01-1.10) were also independent predictors of mortality. In contrast, no individual PFT variable was predictive of mortality once HRCT patterns were accounted for. |
2 |
| 82. Morell F, Villar A, Montero MA, et al. Chronic hypersensitivity pneumonitis in patients diagnosed with idiopathic pulmonary fibrosis: a prospective case-cohort study. The Lancet Respiratory Medicine. 1(9):685-94, 2013 Nov. |
Observational-Dx |
60 patients |
To investigate occult, putative causes in the environments of patients diagnosed with idiopathic pulmonary fibrosis (IPF) using tests beyond those conventionally used. |
20 of the 46 (43%, 95% CI 29-58) patients with IPF according to 2011 guidelines had a subsequent diagnosis of chronic hypersensitivity pneumonitis: nine patients had positive bronchial challenge testing (eight of whom were also IgG positive and six of these patients also had surgical lung biopsy showing a pattern consistent with chronic hypersensitivity pneumonitis); seven were IgG positive plus had histopathology on surgical lung biopsy that was consistent with hypersensitivity pneumonitis; one was IgG positive plus had greater than 20% lymphocytes in bronchoalveolar lavage fluid; and three had findings on surgical lung biopsy that were consistent with subacute hypersensitivity pneumonitis (and IgG positive). Altogether, 29 of 46 patients diagnosed with IPF who had met the 2011 criteria had lung tissue available for histopathology (surgical lung biopsy in 28 patients and explanted lung in two patients, one of whom also had surgical biopsy) during the study period, and 16 of the 20 patients with chronic hypersensitivity pneumonitis had histopathological features on surgical lung biopsy that were consistent with this diagnosis. 26 of the 46 patients remained with a diagnosis of IPF. |
2 |
| 83. Lima MS, Coletta EN, Ferreira RG, et al. Subacute and chronic hypersensitivity pneumonitis: histopathological patterns and survival. Respir Med. 103(4):508-15, 2009 Apr. |
Observational-Dx |
103 patients |
To describe the impact on survival of clinical data, histological patterns, and HRCT findings in subacute/chronic HP. |
The most relevant exposures were to molds and birds. Lung biopsies revealed typicalHP with granulomas in 46 patients, bronchiolocentric interstitial pneumonia in 27, and nonspecificinterstitial pneumonia (NSIP) in 16. By univariate analysis, several findings werepredictors of mortality: older age, male sex, velcro crackles, higher FEV1/FVC ratio, loweroxygen saturation during exercise, and absence of mosaic pattern/air trapping and presenceof fibrosis on HRCT. By multivariate analysis, remained significant: age (p = 0.007), oxygensaturation during exercise (p = 0.003), and mosaic pattern/air trapping on HRCT(p = 0.004). Patients with NSIP had a greater survival than did those with typical histologyand those with bronchiolocentric pneumonia (p= 0.033). |
3 |
| 84. Chung JH, Zhan X, Cao M, et al. Presence of Air Trapping and Mosaic Attenuation on Chest Computed Tomography Predicts Survival in Chronic Hypersensitivity Pneumonitis. Ann Am Thorac Soc. 14(10):1533-1538, 2017 Oct. |
Observational-Dx |
110 patients |
To examine whether the presence of CT mosaic attenuation (MA) and air trapping (AT), and the distribution or patterns of fibrosis impact survival in subjects with chronic HP. |
Fibrotic HP (65%; 72/110) was most often peripheral in the axial plane and lower lung preponderant. The distribution of lung disease in those without fibrosis was most often axially and zonally diffuse. There was no association between survival and CT distribution or CT pattern in the whole cohort or within the fibrotic subset of subjects. After multivariate adjustment, AT/MA was independently associated with survival in the whole cohort (HR?=?0.26; 95% confidence interval?=?0.07-0.97). Results were similar after restricting the analyses to fibrotic HP cases. |
2 |
| 85. Chung JH, Montner SM, Adegunsoye A, et al. CT findings associated with survival in chronic hypersensitivity pneumonitis. Eur Radiol. 27(12):5127-5135, 2017 Dec. |
Observational-Dx |
132 patients |
To identify CT findings in chronic hypersensitivity pneumonitis (cHP) associated with survival. |
The majority of subjects had an inconsistent with usual interstitial pneumonitis pattern on CT (55.3%,73/132). Hypersensitivity pneumonitis (HP) diagnosis on CT was less common in those with fibrosis (66.1%, 74/112) than those without fibrosis (85%,17/20). Smoking was associated with a lower prevalence of HP on CT (p=0.04). CT features of pulmonary fibrosis, especially traction bronchiectasis (HR 8.34, 95% CI 1.98-35.21) and increased pulmonary artery (PA)/aorta ratio (HR 2.49, 95% CI 1.27-4.89) were associated with worse survival, while ground-glass opacity (HR 0.31, 95% CI 0.12-0.79) was associated with improved survival. Survival association with imaging was less pronounced after adjustment for gender, age and physiology score. |
1 |
| 86. Jacob J, Bartholmai BJ, Egashira R, et al. Chronic hypersensitivity pneumonitis: identification of key prognostic determinants using automated CT analysis. BMC polm. med.. 17(1):81, 2017 May 04. |
Observational-Dx |
116 patients |
To identify a subset of Chronic hypersensitivity pneumonitis (CHP) patients with an outcome similar to patients with idiopathic pulmonary fibrosis (IPF). |
In CHP, visual/CALIPER measures of reticular pattern, honeycombing, visual traction bronchiectasis, and CALIPERILD extent were predictive of mortality (p < 0 · 05) on univariate analysis. PVV was strongly predictive of mortality onunivariate (p < 0 · 0001) and multivariate analysis independent of age, gender and disease severity (representedby the CPI [p < 0 · 01]). CHP patients with a PVV threshold >6 · 5% of the lung had a mean survival (35 · 3 ± 6 · 1 months;n = 20/116 [17%]) and rate of disease progression that closely matched IPF patients (38 · 4 ± 2 · 2 months; n = 185). |
2 |
| 87. Jacob J, Bartholmai BJ, Rajagopalan S, et al. Automated computer-based CT stratification as a predictor of outcome in hypersensitivity pneumonitis. Eur Radiol. 27(9):3635-3646, 2017 Sep. |
Observational-Dx |
98 patients |
To analyze CT imaging scored visually and by CALIPER in patients with Hypersensitivity pneumonitis (HP) to identify variables predictive of mortality using proportional hazards regression analysis. |
Univariate predictors of mortality included visual and CALIPER CT fibrotic patterns, and all functional indices. Multivariate analyses identified only two independent predictors of mortality: CALIPER reticular pattern (p?=?0.001) and DLco (p?<?0.0001). Automated stratification distinguished three distinct HP groups (log-rank test p?<?0.0001). Substitution of automated stratified groups for FVC and DLco in the ILD-GAP model demonstrated no loss of model strength (C-Index?=?0.73 for both models). Model strength improved when automated stratified groups were combined with the ILD-GAP model (C-Index?=?0.77). |
2 |
| 88. Hanak V, Golbin JM, Hartman TE, Ryu JH. High-resolution CT findings of parenchymal fibrosis correlate with prognosis in hypersensitivity pneumonitis. Chest. 134(1):133-8, 2008 Jul. |
Observational-Dx |
69 patients |
To review High-resolution CT findings of parenchymal fibrosis. |
Of 69 patients, 26 were classified as fibrotic and 43 as nonfibrotic. Patients in the fibrotic group were older, had longer symptom duration, were more likely to have crackles on auscultation, more likely to be exposed to avian antigen, and had greater restrictive lung impairment (p<0.05 for all comparisons). There were 11 deaths in the fibrotic group and 1 death in the nonfibrotic group (p<0.0001). In the regression analysis, CT evidence of fibrosis, more severe pulmonary function abnormalities, and the presence of crackles on auscultation were predictive of reduced survival (p<0.05 for all). The presence as well as the extent of fibrosis on CT was associated with increased mortality. The age-adjusted hazard ratio for mortality in patients with fibrosis was 4.6 (95% confidence interval, 2.0 to 20.1; p<0.0001). |
2 |
| 89. Mooney JJ, Elicker BM, Urbania TH, et al. Radiographic fibrosis score predicts survival in hypersensitivity pneumonitis. Chest. 144(2):586-592, 2013 Aug. |
Observational-Dx |
177 patients |
To review whether the radiographic fibrosis score predicts mortality in persistent hypersensitivity pneumonitis (HP) and if survival is similar to that observed in idiopathic pulmonary fibrosis (IPF) when adjusting for the extent of radiographic fibrosis. |
HRCT scan fibrosis score and radiographic reticulation independently predicted time to death or lung transplantation. Clinical predictors included a history of cigarette smoking, auscultatory crackles on lung examination, baseline FVC, and FEV1/FVC ratio. The majority of HP deaths occurred in patients with both radiographic reticulation and auscultatory crackles on examination, compared with patients with only one of these manifestations (P < .0001). Patients with IPF had worse survival than those with HP at any given degree of radiographic fibrosis (hazard ratio 2.31; P < .01). |
1 |
| 90. Tateishi T, Ohtani Y, Takemura T, et al. Serial high-resolution computed tomography findings of acute and chronic hypersensitivity pneumonitis induced by avian antigen. J Comput Assist Tomogr. 35(2):272-9, 2011 Mar-Apr. |
Observational-Dx |
112 patients |
To evaluate serial changes and the prognostic value of high-resolution computed tomographic (HRCT) findings in hypersensitivity pneumonitis (HP). |
Ground-glass opacities and centrilobular nodules were predominant findings in acute and recurrent HP, whereas honeycombing was the outstanding feature in insidious HP. Areas of ground-glass opacities and centrilobular nodules decreased in all groups over a long-term follow-up. Areas of honeycombing, on the other hand, increased in chronic HP, especially in the insidious cases. Cox regression models revealed a higher mortality risk in cases with airspace consolidation and honeycombing on HRCT. |
2 |
| 91. Morisset J, Johannson KA, Vittinghoff E, et al. Use of Mycophenolate Mofetil or Azathioprine for the Management of Chronic Hypersensitivity Pneumonitis. Chest. 151(3):619-625, 2017 03. |
Observational-Tx |
70 patients |
To determine the effect of treatment with mycophenolate mofetil (MMF) or azathioprine (AZA) on lung function in patients with cHP. |
Seventy patients were included: 51 were treated withMMFand 19 with AZA. Medianfollow-up after treatment initiation was 11 months. Prior to treatment initiation, FVC anddiffusion capacity of the lung for carbon monoxide (DLCO)%predicted were declining at ameanrate of 0.12% (P < .001) and 0.10% (P < .001) per month, respectively. Treatment with eitherMMF or AZA was not associated with improved FVC (0.5% at 1 year; P ¼ .46) but was associatedwith a statistically significant improvement in DLCO of 4.2% (P < .001) after 1 year oftreatment. Results were similar in the subgroup of patients treated with MMF for 1 year; theFVC increased nonsignificantly by 1.3% (P ¼ .103) and DLCO increased by 3.9% (P < .001). |
2 |
| 92. van Rooy FG, Rooyackers JM, Prokop M, Houba R, Smit LA, Heederik DJ. Bronchiolitis obliterans syndrome in chemical workers producing diacetyl for food flavorings. Am J Respir Crit Care Med. 176(5):498-504, 2007 Sep 01. |
Review/Other-Dx |
175 patients |
To investigate the risk of bronchiolitis obliterans for chemical workers producing diacetyl, with exposure to less complex mixtures of chemicals. |
Workers with fixed airway obstruction underwent further pulmonary function testing (including diffusing capacity and lung volumes) and paired inspiratory and expiratory high-resolution computed tomography studies. We identified three cases consistent with bronchiolitis obliterans syndrome with air trapping on high-resolution computed tomography of the lungs, in the highest exposure group of 102 process operators. Two of these cases were lifelong nonsmokers. Potential exposures included acetoin, diacetyl, acetaldehyde, and acetic acid, with diacetyl exposures in the range previously reported to be associated with fixed airway obstruction in the microwave popcorn industry. |
4 |
| 93. Park HJ, Park SH, Im SA, Kim YK, Lee KY. CT differentiation of anthracofibrosis from endobronchial tuberculosis. AJR Am J Roentgenol. 191(1):247-51, 2008 Jul. |
Observational-Dx |
43 patients with anthracofibrosis and 32 patients with endobronchial TB |
To use CT to differentiate anthracofibrosis from endobronchial tuberculosis (TB), both of which are major causes of benign bronchostenosis. |
Anthracofibrosis was more common than endobronchial TB among elderly patients (p < 0.05). Statistically significant findings on CT were the pattern of bronchostenosis, presence of main bronchus involvement, and number of pulmonary lobes involved (p < 0.05). Bronchostenosis with anthracofibrosis usually involves multiple lobar or segmental bronchi. The main bronchus, however, tends to be preserved in anthracofibrosis. Most cases of endobronchial TB involve one lobar bronchus and the ipsilateral main bronchus with contiguity in extent. |
3 |
| 94. Han FF, Yang TY, Song L, et al. Clinical and pathological features and imaging manifestations of bronchial anthracofibrosis: the findings in 15 patients. Chin Med J. 126(14):2641-6, 2013 Jul. |
Review/Other-Dx |
15 patients |
To study the clinical features and imaging manifestations of BAF, and to promote the awareness of this disease. |
A total of 15 patients were analyzed; 13 were female (86.7%) and two were male (13.3%) and the age range was from 62 to 86 years with a mean age of 74.5 years. Three cases (20.0%) had a history of tuberculosis. The most common clinical symptoms of BAF were cough (100%), expectoration (73.3%), dyspnea (60.0%), and fever (46.7%). Twelve cases displayed mild to moderate obstructive ventilatory dysfunction. In the electronic bronchoscopic evaluation, the most common findings were black bronchial mucosal pigmentation, bronchial stenosis, bronchial occlusion, and bronchial mucosal folds. Pathological evaluation revealed chronic inflammation of the bronchial mucosa, submucosal carbon particle deposition, and mucosal or submucosal fibrosis. Chest CT scans showed that 15 patients had bronchial stenosis or obstruction (direct signs) with the right middle lobe being the most common site (11 cases, 73.3%). The indirect sign was mainly the presence of bronchial obstructive diseases (including secondary infection), represented by 11 cases of pulmonary consolidation (73.3%), seven cases of atelectasis (46.7%), and five cases of nodules (33.3%). The CT mediastinal window showed bronchial lymph node lesions, mediastinal lymph node calcification (12 cases, 80.0%), and enlargement of multiple mediastinal lymph nodes. |
4 |
| 95. Mathew L, Kirby M, Etemad-Rezai R, Wheatley A, McCormack DG, Parraga G. Hyperpolarized 3He magnetic resonance imaging: preliminary evaluation of phenotyping potential in chronic obstructive pulmonary disease. Eur J Radiol. 79(1):140-6, 2011 Jul. |
Observational-Dx |
20 patients |
To quantify hyperpolarized helium-3 ((3)He) magnetic resonance imaging (MRI) functional and structural measurements and to explore the potential role for (3)He MRI in detecting the lung structural and functional COPD phenotypes. |
Based on the relative contribution of normalized ADC and VDP, there was evidence of a predominant (3)He MRI measurement in seven patients (n=3 mainly ventilation defects or VDP dominant (VD), n=4 mainly increased ADC or ADC dominant (AD)). Analysis of variance (ANOVA) showed significantly lower ADC for subjects with predominantly elevated VDP (p=0.02 compared to subjects with predominantly elevated ADC; p=0.008 compared to mixed group) and significantly decreased VDP for subjects with predominantly elevated ADC (p=0.003, compared to mixed group). |
2 |
| 96. Zha W, Kruger SJ, Cadman RV, et al. Regional Heterogeneity of Lobar Ventilation in Asthma Using Hyperpolarized Helium-3 MRI. Acad Radiol. 25(2):169-178, 2018 Feb. |
Observational-Dx |
82 patients |
To determine lobar ventilation patterns in asthmatic lungs with hyperpolarized 3He magnetic resonance imaging (HP 3He MRI). |
In mild-to-moderate asthma, the RML and RUL showed significantly greater VDP than the two lower lobes (RLL and LLL) (P?=?.047). In severe asthma, the pattern was more variable with the VDP in the RUL significantly greater than in the RLL (P?=?.026). In both asthma groups, the lower lobes (RLL and LLL) showed significantly higher high ventilation percent and Hs compared to the three upper lobes (all P?=?.015). |
2 |
| 97. Tahir BA, Van Holsbeke C, Ireland RH, et al. Comparison of CT-based Lobar Ventilation with 3He MR Imaging Ventilation Measurements. Radiology. 278(2):585-92, 2016 Feb. |
Observational-Dx |
30 patients |
To compare lobar lung ventilation computed from expiratory and inspiratory computed tomographic (CT) data with direct measurements of ventilation at hyperpolarized helium 3 (3He) magnetic resonance (MR) imaging by using same-breath hydrogen 1 (1H) MR imaging examinations to coregister the multimodality images. |
The mean +- standard deviation absolute difference between the CT and 3He MR imaging percentage of ventilation volume in all lobes was 4.0% (right upper and right middle lobes, 5.4% +- 3.3; right lower lobe, 3.7% +- 3.9; left upper lobe, 2.8% +- 2.7; left lower lobe, 3.9% +- 2.6; Wilcoxon signed-rank test, P < .05). The Pearson correlation coefficient between the two techniques in all lobes was 0.65 (P < .001). Greater percentage of ventilation was seen in the upper lobes with 3He MR imaging and in the lower lobes with CT. This was confirmed with BlandAltman analysis, with 95% limits of agreement for right upper and middle lobes, -2.4, 12.7; right lower lobe, -11.7, 4.6; left upper lobe, -4.9, 8.7; and left lower lobe, -9.8, 2.8. |
3 |
| 98. Gast KK, Viallon M, Eberle B, et al. MRI in lung transplant recipients using hyperpolarized 3He: comparison with CT. J Magn Reson Imaging. 15(3):268-74, 2002 Mar. |
Observational-Dx |
14 patients |
To elucidate the ability of 3He-MRI to detect ventilation defects in lung transplant recipients, 3He-MRI was compared to CT for concordance. |
Altogether, 59 representative ventilation defectswere defined on 3He-MRI. Plausible CT correlates werefound for 29 ventilation defects; less plausible CT correlateswere found for eight defects. In 22 defects (37%) no correspondingCT changes were detected. CT demonstrated correlatesfor ventilation defects seen on 3He-MRI in only 63% of the cases. |
2 |
| 99. Puderbach M, Eichinger M, Haeselbarth J, et al. Assessment of morphological MRI for pulmonary changes in cystic fibrosis (CF) patients: comparison to thin-section CT and chest x-ray. Invest Radiol. 42(10):715-25, 2007 Oct. |
Observational-Dx |
31 patients |
To prospectively assess the value of MRI for evaluation of morphologic pulmonary CF-changes in comparison to established imaging modalities. |
The median MRI and MDCT scores were 13 (min 3, max 20) respectively 13.5 (min 0, max 20). The median chest x-ray score was 14 (min 5, max 32). Pearson correlation coefficients: MRI/CT = 0.80, P < 0.0001; MRI/chest x-ray = 0.63, P < 0.0018; chest x-ray/CT = 0.75, P < 0.0001. The median lobe related concordance was 80% for bronchiectasis, 77% for mucus plugging, 93%, for sacculation/abscesses, and 100% for collapse/consolidation. |
2 |
| 100. Capaldi DPI, Eddy RL, Svenningsen S, et al. Free-breathing Pulmonary MR Imaging to Quantify Regional Ventilation. Radiology. 287(2):693-704, 2018 05. |
Observational-Dx |
30 patients |
To measure regional specific ventilation with free-breathing hydrogen 1 (1H) magnetic resonance (MR) imaging without exogenous contrast material and to investigate correlations with hyperpolarized helium 3 (3He) MR imaging and pulmonary function test measurements in healthy volunteers and patients with asthma |
Thirty subjects (median age: 50 years; interquartile range [IQR]: 30 years), including 23 with asthma and seven healthy volunteers, were evaluated. Both 1H MR imaging-derived specific ventilation and hyperpolarized 3He MR imaging-derived ventilation percentage were significantly greater in healthy volunteers than in patients with asthma (specific ventilation: 0.14 [IQR: 0.05] vs 0.08 [IQR: 0.06], respectively, P < .0001; ventilation percentage: 99% [IQR: 1%] vs 94% [IQR: 5%], P < .0001). For all subjects, 1H MR imaging-derived specific ventilation correlated with plethysmography-derived specific ventilation (? = 0.54, P = .002) and hyperpolarized 3He MR imaging-derived ventilation percentage (? = 0.67, P < .0001) as well as with forced expiratory volume in 1 second (FEV1) (? = 0.65, P = .0001), ratio of FEV1 to forced vital capacity (? = 0.75, P < .0001), ratio of residual volume to total lung capacity (? = -0.68, P < .0001), and airway resistance (? = -0.51, P = .004). 1H MR imaging-derived specific ventilation was significantly greater in the gravitational-dependent versus nondependent lung in healthy subjects (P = .02) but not in patients with asthma (P = .1). In patients with asthma, coregistered 1H MR imaging specific ventilation and hyperpolarized 3He MR imaging maps showed that specific ventilation was diminished in corresponding 3He MR imaging ventilation defects (0.05 ± 0.04) compared with well-ventilated regions (0.09 ± 0.05) (P < .0001). Conclusion 1H MR imaging-derived specific ventilation correlated with plethysmography-derived specific ventilation and ventilation defects seen by using hyperpolarized 3He MR imaging. © RSNA, 2018 Online supplemental material is available for this article. |
2 |
| 101. Kuramochi J, Inase N, Miyazaki Y, Kawachi H, Takemura T, Yoshizawa Y. Lung cancer in chronic hypersensitivity pneumonitis. Respiration. 82(3):263-7, 2011. |
Review/Other-Dx |
11 patients |
We examined the prevalence and revealed clinical features of lung cancer in chronic hypersensitivity pneumonitis (CHP) |
Ten men and 1 woman with a median age of 68.9 years wereincluded. All patients had a smoking history. The most prevalenthistopathological type of lung cancer was squamouscell carcinoma (53%), and all tumors were located in the peripheralregion of the lung. Four patients suffered from lungcancer after the diagnosis of CHP and 1 patient had lung cancerbefore the diagnosis of CHP. The histological pattern ofCHP showed a predominantly usual interstitial pneumonialikelesion. Tumors were located adjacent to honeycombingin 7 (47%) of 15 lesions, bullae in 4 (27%) lesions, and relativelynormal lung in 4 lesions. |
4 |
| 102. Hung YP, Teng CJ, Liu CJ, et al. Cancer risk among patients with coal workers' pneumoconiosis in Taiwan: a nationwide population-based study. Int J Cancer. 134(12):2910-6, 2014 Jun 15. |
Observational-Dx |
6895 males and 1156 females |
To evaluate the cancer risk among patients with coal workers’ pneumoconiosis (CWP) using a nationwide population-based dataset. |
After a median follow-up of 9.68 years, 954 cancers developed among8,051 recruited CWP patients, with a follow-up of 69,398 person-years. The SIR for all cancers was 1.12 [95% confidenceinterval (CI) 1.04–1.18]. Males older than 80 years had a SIR of 1.27 (95% CI: 1.06–1.51). The SIRs of esophageal (1.76, 95%CI: 1.24–2.44), gastric (1.42, 95% CI: 1.13–1.76), liver and biliary tract (1.18, 95% CI: 1.01–1.37) and lung and mediastinal(1.45, 95% CI: 1.26–1.66) cancers were significantly higher in the CWP group than in the general population. Multivariateanalysis showed that age60 years [hazard ratio (HR) 1.70, 95% CI: 1.41–2.05), male gender (HR51.79, 95% CI:1.44–2.23) and liver cirrhosis (HR53.99, 95% CI: 2.89–5.51) were significant predictors of cancer development in patientswith CWP. |
3 |
| 103. Fitzgerald NR, Flanagan WM, Evans WK, Miller AB, Canadian Partnership against Cancer (CPAC) Cancer Risk Management (CRM) Lung Cancer Working. Eligibility for low-dose computerized tomography screening among asbestos-exposed individuals. Scand J Work Environ Health. 41(4):407-12, 2015 Jul. |
Review/Other-Dx |
N/A |
To incorporate an estimate of risk for asbestos exposure in the Canadian Cancer Risk Management Lung Cancer (CRMM-LC) microsimulation model. |
As annual LDCT screening among non-asbestos-exposed individuals is less cost-effective than biennialscreening, all the scenarios modeled for an asbestos-exposed cohort were biennial. For individuals with atwo-fold risk of asbestos-induced lung cancer to be eligible for biennial LDCT screening, a smoking history of=15 pack-years would be necessary. For non-smokers with asbestos exposure resulting in a relative risk (RR)for lung cancer, it is not cost-effective to screen those with a RR of 5, but it is cost-effective to screen those witha RR of 10 (the heavily exposed). |
4 |
| 104. Das M, Muhlenbruch G, Mahnken AH, et al. Asbestos Surveillance Program Aachen (ASPA): initial results from baseline screening for lung cancer in asbestos-exposed high-risk individuals using low-dose multidetector-row CT. Eur Radiol. 2007;17(5):1193-1199. |
Review/Other-Dx |
187 individuals |
To assess the prevalence of lung cancer in a high-risk asbestos-exposed cohort using low-dose MDCT. |
One strongly suspicious mass and eight cases of histologically proven lung cancer were found plus 491 additional pulmonary nodules (average volume: 40.72 ml, average diameter 4.62 mm). Asbestos-related changes (pleural plaques, fibrosis) were visible in 80 individuals. Lung cancer screening in this high-risk cohort showed a prevalence of lung cancer of 4.28% (8/187) at baseline screening with an additional large number of indeterminate pulmonary nodules. Low-dose MDCT proved to be feasible in this highly selected population. |
4 |
| 105. Roberts HC, Patsios DA, Paul NS, et al. Screening for malignant pleural mesothelioma and lung cancer in individuals with a history of asbestos exposure. J Thorac Oncol. 4(5):620-8, 2009 May. |
Review/Other-Dx |
516 asbestos-exposed individuals |
To establish a screening program for prior asbestos workers using low-dose computed tomography (LDCT). |
We included 507 men and 9 women (median 60.0 years),395 (76.6%) were smokers. Annual repeat has been performed in356 participants. We found plaques in 357 subjects (69.2%), commonlycalcified (79.6%), flat (86.6%), and symmetric (86.8%), andmostly involving the costal (96.4%) and diaphragmatic (81.8%)pleura. Uncommon plaques were lobulated (13.2%), right-dominantasymmetric (4.5%), or with effusions (0.1%).We found pulmonary nodules in 371 subjects (71.9%), 91(17.6%) had at least one nodule >=5mm; 10 growing noduleswere found on annual repeat LDCT. In 41 individuals, plaqueswere regarded as atypical; three had new pleural/peritoneal abnormalitieson annual repeat LDCT. An interim limited computedtomography of the observed abnormality prompted 10 diagnosticbiopsies, resulting in a diagnosis of six lung cancers, two pleuralmesothelioma and two peritoneal mesothelioma; overall rate ofscreen-detected malignancies is 2.1%. There were four intervalcancers, diagnosed after baseline (n = 1) or after the annualrepeat (n = 3): two pleural and one peritoneal mesothelioma, andone mixed squamous/small cell carcinoma. |
4 |
| 106. Pairon JC, Andujar P, Rinaldo M, et al. Asbestos exposure, pleural plaques, and the risk of death from lung cancer. Am J Respir Crit Care Med. 190(12):1413-20, 2014 Dec 15. |
Observational-Dx |
17 cases |
To examine the association between pleural plaques on computed tomography (CT) scan and the risk of pleural mesothelioma in a follow-up study of asbestos-exposed workers. |
A total of 17 incident cases of pleural mesothelioma were diagnosed. A statistically significant association wasobserved between mesothelioma and pleural plaques (unadjusted hazard ratio (HR) = 8.9, 95% confidence interval[CI] = 3.0 to 26.5; adjusted HR = 6.8, 95% CI = 2.2 to 21.4 after adjustment for time since first exposure andcumulative exposure index to asbestos). |
1 |
| 107. Pairon JC, Laurent F, Rinaldo M, et al. Pleural plaques and the risk of pleural mesothelioma. J Natl Cancer Inst. 105(4):293-301, 2013 Feb 20. |
Observational-Dx |
5287 subjects |
To examine the association between pleural plaques on computed tomography (CT) scan and the risk of pleural mesothelioma in a follow-up study of asbestos-exposed workers. |
A total of 17 incident cases of pleural mesothelioma were diagnosed. A statistically significant association wasobserved between mesothelioma and pleural plaques (unadjusted hazard ratio (HR) = 8.9, 95% confidence interval[CI] = 3.0 to 26.5; adjusted HR = 6.8, 95% CI = 2.2 to 21.4 after adjustment for time since first exposure andcumulative exposure index to asbestos). |
1 |
| 108. Vierikko T, Jarvenpaa R, Autti T, et al. Chest CT screening of asbestos-exposed workers: lung lesions and incidental findings. Eur Respir J. 2007;29(1):78-84. |
Observational-Dx |
633 workers |
To determine the feasibility of chest computed tomography (CT) in screening for lung cancer among asbestos-exposed workers. |
Noncalcified lung nodules were detected in 86 workers. Five histologically confirmed lung cancers were found. Only one of the five cancers was also detected by plain chest radiography and three were from the group of patients with a pre-estimated lower cancer probability. Two lung cancers were stage Ia and were radically operated. In total, 277 individuals presented 343 incidental findings of which 46 required further examination. Four of these were regarded as clinically important. Computed tomography and high-resolution computed tomography proved to be superior to plain radiography in detecting lung cancer in asbestos-exposed workers with many confounding chest findings. The numerous incidental findings are a major concern for future screenings, which should be considered for asbestos-exposed ex-smokers and current smokers. |
2 |
| 109. Hallifax RJ, Haris M, Corcoran JP, et al. Role of CT in assessing pleural malignancy prior to thoracoscopy. Thorax. 2015;70(2):192-193. |
Review/Other-Dx |
370 patients |
To assess the sensitivity and specificity of computed tomography (CT) in detecting pleural malignancy prior to definitive histology obtained via thoracoscopy in a large cohort of patients with suspected malignant pleural disease. |
211 (57%) of 370 patients included in the analysis had malignant disease: CT scans were reported as 'malignant' in 144, giving a sensitivity of 68% (95% CI 62% to 75%). Of the 159 patients with benign disease, 124 had CT scans reported as benign: specificity 78% (72% to 84%). The positive predictive value of a malignant CT report was 80% (75% to 86%), with a negative predictive value of 65% (58% to 72%). A significant proportion of patients being investigated for malignant disease will have malignancy despite a negative CT report. |
4 |
| 110. Kato K, Gemba K, Ashizawa K, et al. Low-dose chest computed tomography screening of subjects exposed to asbestos. European Journal of Radiology. 101:124-128, 2018 Apr. |
Observational-Dx |
2132 patients |
To reveal the prevalence of lung cancer (LC) and malignant pleural mesothelioma (MPM) in subjects with past asbestos exposure (AE). |
The PQs were detected in most of subjects (89.4%) and emphysema changes were seen in 46.0%. Fibrotic changes were detected in 565 cases (26.5%). A pathological diagnosis of LC was confirmed in 45 cases (2.1%) and MPM was confirmed in 7 cases (0.3%). The prevalence of LC was 2.5% in patients with a smoking history, which was significantly higher than that in never smokers (0.7%, p?=?0.027). The prevalence of LC was 2.8% in subjects with emphysema changes, which was higher than that of subjects without those findings (1.6%); although, the difference was not statistically significant (p?=?0.056). The prevalence of LC in subjects with both fibrotic plus emphysema changes was 4.0%, which was significantly higher than that of subjects with neither of those findings (1.8%, p?=?0.011). Logistic regression analysis revealed smoking history, fibrotic plus emphysema changes, and pleural effusion as significant explanatory variables. |
2 |
| 111. Tsim S, Stobo DB, Alexander L, Kelly C, Blyth KG. The diagnostic performance of routinely acquired and reported computed tomography imaging in patients presenting with suspected pleural malignancy. Lung Cancer. 103:38-43, 2017 01. |
Observational-Dx |
315 CT scans |
To reassess the performance of routinely acquired and reported CT in a less selected population |
30/345 (9%) eligible patients were excluded (non-contrast (n = 13) or non-contiguous CT (n = 4),incomplete follow-up (n = 13)). 195/315 (62%) patients studied had PM; 90% were cyto-histologicallyconfirmed. 172/315 (55%) presented as an acute admission, of whom 31/172 (18%) had CTPA. Overall,CT sensitivity was 58% (95% CI 51–65%); specificity was 80% (95% CI 72–87%). Sensitivity of CTPA (per-formed in 31/315 (10%)) was lower (27% (95% CI 9–53%)) than venous-phase CT (61% (95% CI 53–68%)p = 0.0056). Sensitivity of specialist thoracic radiologist reporting was higher (68% (95% CI 55–79%)) thannon-specialist reporting (53% (95% CI 44–62%) p = 0.0488). Specificity was not significantly different. |
3 |
| 112. de Groot PM, Chung JH, Ackman JB, et al. ACR Appropriateness Criteria® Noninvasive Clinical Staging of Primary Lung Cancer. J Am Coll Radiol 2019;16:S184-S95. |
Review/Other-Dx |
N/A |
Evidence-based guidelines to assist referring physicians and other providers in making the most appropriate imaging or treatment decision for noninvasive clinical staging of primary lung cancer. |
No results stated in abstract. |
4 |
| 113. Ogihara Y, Ashizawa K, Hayashi H, et al. Progressive massive fibrosis in patients with pneumoconiosis: utility of MRI in differentiating from lung cancer. Acta Radiol. 59(1):72-80, 2018 Jan. |
Observational-Dx |
28 patients |
To evaluate the magnetic resonance imaging (MRI) features of progressive massive fibrosis (PMF) and to assess its ability to differentiate PMF from lung cancer. |
All 24 PMF lesions showed low signal intensity (SI) on T2WIs (sensitivity, 100%), while 15 of 16 lung cancer lesions showed intermediate or high SI on T2WIs (specificity, 94%) when PMF was regarded as a positive result. Six of 17 PMF lesions showed a homogeneous enhancement pattern (sensitivity, 35%), and four of 9 lung cancer lesions showed an inhomogeneous or a ring-like enhancement pattern (specificity, 44%). Six of 16 PMF lesions showed a gradually increasing enhancement pattern (sensitivity, 38%), and seven of 9 lung cancer lesions showed rapid enhancement pattern (specificity, 78%). |
2 |
| 114. Gill RR, Umeoka S, Mamata H, et al. Diffusion-weighted MRI of malignant pleural mesothelioma: preliminary assessment of apparent diffusion coefficient in histologic subtypes. AJR Am J Roentgenol. 2010;195(2):W125-130. |
Observational-Dx |
62 patients |
To prospectively assess, in the evaluation of patients with suspected malignant pleural mesothelioma (MPM), apparent diffusion coefficient (ADC) values derived from diffusion-weighted images obtained with a free-breathing single-shot spin-echo echo-planar imaging sequence and to correlate the ADC values with the three histologic subtypes of MPM. |
Fifty-seven patients had MPM. Forty of the tumors were epithelioid, 11 were biphasic, and six were sarcomatoid. The other five patients had pleural thickening (two patients), metastatic adenocarcinoma (one patient), chronic inflammation (one patient), and malignant lymphoma (one patient). Because of image distortion, the diffusion-weighted images and ADC maps were not satisfactory for assessment in seven cases. The ADC values of MPM were 1.31 +/- 0.15 x 10(-3) mm(2)/s for the epithelioid, 1.01 +/- 0.11 x 10(-3) mm(2)/s for the biphasic, and 0.99 +/- 0.07 x 10(-3) mm(2)/s for the sarcomatoid subtypes of MPM. The ADC of the epithelioid subtype was statistically significantly higher than that of the sarcomatoid subtype (p < 0.05). The ADC in the two cases of benign plaque was 0.85 +/- 0.17 x 10(-3) mm(2)/s. |
3 |
| 115. Patel AM, Berger I, Wileyto EP, et al. The value of delayed phase enhanced imaging in malignant pleural mesothelioma. J. thorac. dis.. 9(8):2344-2349, 2017 Aug. |
Observational-Dx |
42 patients |
To estimate the optimal timing of malignant pleural mesothelioma (MPM) enhancement on magnetic resonance imaging (MRI). |
Of the 42 MPM patients who had undergone staging MRI during the study period, 12 patientsmet the study criteria. Peak tumor enhancement was between 150 and 300 sec following IV contrastadministration. Within this time window, 80% of patients are projected to have reached >80%, >85%, and>90% peak tumor enhancement. There was a statistically significant correlation between increasing tumorenhancement and subjective lesion conspicuity. |
2 |
| 116. Usuda K, Maeda S, Motono N, et al. Diagnostic Performance of Diffusion-Weighted Imaging for Multiple Hilar and Mediastinal Lymph Nodes with FDG Accumulation. Asian Pac J Cancer Prev. 16(15):6401-6, 2015. |
Observational-Dx |
23 patients |
To review the diagnostic performance of Diffusion-Weighted Imaging for Multiple Hilar and Mediastinal Lymph Nodes with FDG Accumulation. |
For diagnosis of disease, there were 20 malignancies (lung cancers 17, malignant lymphomas 2 and metastatic lung tumor 1), and 3 benign cases (sarcoidosis 2 and benign disease 1). For diagnosis of lymph nodes, there were 7 malignancies (metastasis of lung cancer 7 and malignant lymphoma 1) and 16 benign lymphadenopathies (pneumoconiosis/silicosis 7, sarcoidosis 4, benign disease 4, and atypical lymphocyte infiltration 1). The ADC value (1.57±0.29x10(-3) mm2/sec) of malignant MHMLN was significantly lower than that (1.99±0.24x10(-3) mm2/sec) of benign MHMLN (P=0.0437). However, the SUVmax was not significantly higher (10.0±7.34 as compared to 6.38±4.31) (P=0.15). The sensitivity (86%) by PET-CT was not significantly higher than that (71%) by DWI for malignant MHMLN (P=1.0). The specificity (100%) by DWI was significantly higher than that (31%) for benign MHMLN (P=0.0098). Furthermore, the accuracy (91%) with DWI was significantly higher than that (48%) with PET-CT for MHMLN (P=0.0129). |
2 |
| 117. Weber MA, Bock M, Plathow C, et al. Asbestos-related pleural disease: value of dedicated magnetic resonance imaging techniques. Invest Radiol. 2004;39(9):554-564. |
Observational-Dx |
21 patients |
To compare respiratory-gated high-spatial resolution magnetic resonance imaging (MRI) and radial MRI with ultra-short echo times with computed tomography (CT) in the diagnosis of asbestos-related pleural disease. |
The MRI protocol allowed for differentiation between normal pleura and pleura with plaques. Interobserver agreement was comparable for MRI and CT in detecting pleural plaques (median kappa = 0.72 for MRI and 0.73 for CT) and significantly higher with CT than with MRI for detection of plaque calcification (median kappa 0.86 for CT and 0.72 for MRI; P = 0.03). Median sensitivity of MRI was 88% for detection of plaque calcification compared with CT. For assessment of pleural thickening, pleural effusion, and extrapleural fat, interobserver agreement with MRI was significantly higher than with CT (median kappa 0.71 and 0.23 for pleural thickening, 0.87 and 0.62 for pleural effusion, and 0.7 and 0.56 for extrapleural fat, respectively; P < 0.05). For detection of mesothelioma, median kappa was 0.63 for MRI and 0.58 for CT. |
2 |
| 118. Chung SY, Lee JH, Kim TH, Kim SJ, Kim HJ, Ryu YH. 18F-FDG PET imaging of progressive massive fibrosis. Ann Nucl Med. 24(1):21-7, 2010 Jan. |
Observational-Dx |
9 patients |
To evaluate (18)F-FDG PET features of progressive massive fibrosis (PMF) and to determine the ability of FDG PET to differentiate pure PMF from PMF-associated lung cancer. |
14 masses were detected from nine patients. On chest CT scan, PMF masses were noted with surrounding small nodules and distortion of parenchyma. The size of the lesions ranged from 1.2 to 6.4 cm in maximum diameter. FDG PET scans identified metabolically active lesions in all patients. Maximal SUV ranged from 3.1 to 14.6 and mean SUV ranged from 1.4 to 8.5. |
4 |
| 119. Reichert M, Bensadoun ES. PET imaging in patients with coal workers pneumoconiosis and suspected malignancy. J Thorac Oncol. 2009;4(5):649-651. |
Review/Other-Dx |
6 cases |
A report on cases of coal worker's pneumoconiosis (CWP) and suspected malignancy to determine PET appearance of CWP and its utility for diagnosing lung malignancy. |
On PET imaging 18 of the 19 nodules were hypermetabolic and five of the six patients had at least one nodule that was PET positive. Based on pathologic data and clinical follow-up, none of the six patients had any evidence of malignancy. In this series, PET imaging was often positive in patents with CWP; however, all were false positives with standardized uptake value measurements in the range that are typically seen with malignant nodules. Due to its high rate of false positives, PET imaging seems to be of limited utility in diagnosing malignancy in patients with underlying coal worker's pneumoconiosis. |
4 |
| 120. Yildirim H, Metintas M, Entok E, et al. Clinical value of fluorodeoxyglucose-positron emission tomography/computed tomography in differentiation of malignant mesothelioma from asbestos-related benign pleural disease: an observational pilot study. J Thorac Oncol. 2009;4(12):1480-1484. |
Observational-Dx |
31 patients |
To investigate the role of 18F-FDG positron emission tomography/computed tomography (PET/CT) for differentiating asbestos-related benign pleural disease from malignant mesothelioma. |
18F-FDG PET/CT imaging correctly detected the presence of malignancies in 15 of 17 patients with malignant mesothelioma for sensitivity, specificity, and overall accuracy of 88.2%, 92.9%, and 90.3%, respectively. 18F-FDG PET/CT imaging correctly identified 13 of 14 cases of benign pleural disease. The mean SUV values were 6.5 +/- 3.4 for malignant mesothelioma cases and 0.8 +/- 0.6 for benign pleural diseases (p < 0.001). When we compared the two groups of pleural disease, a cut-off value of 2.2 for SUV gave the best accuracy with 94.1%, 100%, 100%, and 93.3% for sensitivity, specificity, positive predictive value, and negative predictive value, respectively. |
3 |
| 121. Roca E, Laroumagne S, Vandemoortele T, et al. 18F-fluoro-2-deoxy-d-glucose positron emission tomography/computed tomography fused imaging in malignant mesothelioma patients: looking from outside is not enough. Lung Cancer. 79(2):187-90, 2013 Feb. |
Review/Other-Dx |
3 patients |
To review the limitations of PET/CT in the diagnostic evaluation of MM and the importance of histopathological confirmation by thoracoscopy and/or laparoscopy, which remain the most important diagnostic procedures in MM. |
No results stated in the abstract |
4 |
| 122. Pilling J, Dartnell JA, Lang-Lazdunski L. Integrated positron emission tomography-computed tomography does not accurately stage intrathoracic disease of patients undergoing trimodality therapy for malignant pleural mesothelioma. Thorac Cardiovasc Surg. 2010;58(4):215-219. |
Observational-Dx |
20 patients |
To determine whether integrated PET-CT improved the intrathoracic staging of patients undergoing trimodality therapy for MPM. |
PET-CT was performed a median of 119 days (range 2-229) prior to EPP. 16 scans were performed after talc pleurodesis. Nine scans were performed following chemotherapy. PET-CT correctly identified the T stage in 3 patients, overstaged 4 and understaged 17. Six scans failed to identify disease that later proved to be pT4. Nine patients were found to have pN2 disease; PET-CT identified N2 disease with a sensitivity of 11.1 %, specificity of 93 % and accuracy of 66 %. Previous talc pleurodesis did not alter the accuracy of PET-CT staging. |
3 |
| 123. Khouri NF, Stitik FP, Erozan YS, et al. Transthoracic needle aspiration biopsy of benign and malignant lung lesions. AJR Am J Roentgenol. 144(2):281-8, 1985 Feb. |
Observational-Dx |
650 patients |
To review the transthoracic needle aspiration biopsy of benign and malignant lung lesions. |
No results stated in the abstract |
4 |
| 124. Li H, Boiselle PM, Shepard JO, Trotman-Dickenson B, McLoud TC. Diagnostic accuracy and safety of CT-guided percutaneous needle aspiration biopsy of the lung: comparison of small and large pulmonary nodules. AJR Am J Roentgenol. 167(1):105-9, 1996 Jul. |
Observational-Dx |
97 patients |
To compare the diagnostic accuracy and safety of CT-guided percutaneous needle aspiration biopsy of pulmonary nodules less than or equal to 1.5 cm in diameter with those of nodules greater than 1.5 cm in diameter. |
The diagnostic accuracy of CT-guided percutaneous needle aspiration biopsy of large nodules was 96%. The diagnostic accuracy for small nodules was 74%, a statistically significant difference (p < .05). The prevalences of pneumothorax in our population were nearly identical for small and large nodules (22 and 21%, respectively). The prevalence of chest tube placement in our population was approximately 2%. The prevalences of chest tube placement were 0% for small nodules and 3% for large nodules. |
2 |
| 125. Wallace MJ, Krishnamurthy S, Broemeling LD, et al. CT-guided percutaneous fine-needle aspiration biopsy of small (< or =1-cm) pulmonary lesions. Radiology. 2002; 225(3):823-828. |
Observational-Dx |
61 patients |
To determine the accuracy of percutaneous CT-guided biopsy of small lung nodules. |
Overall sensitivity was 82% (32/39); specificity, 100% (18/18); and diagnostic accuracy, 88% (50/57) on the basis of 57 patients being evaluable. Results for 47 0.8-1.0 cm lesions were considerably better (sensitivity, 88%; accuracy, 92%) than those for 10 0.5-0.7 cm lesions (sensitivity, 50%; accuracy, 70%). Sensitivity (75% vs 87%) and accuracy (87% vs 89%) also improved when comparing subpleural (=1.0 cm from pleural surface, n=30) with deeper (>1 cm from pleural surface, n=27) pulmonary lesions, but the improvement did not indicate statistical significance. Core biopsy did not reveal malignancy in any of the nine patients in whom preliminary cytologic results were inconclusive and did not improve diagnostic yield. Thirty-eight (62%) patients had pneumothorax, with 19 (31%) requiring thoracostomy tube placement. CT-guided FNA biopsy of pulmonary lesions =1.0 cm can yield high diagnostic accuracy rates approaching those of larger lesions; FNA biopsy of 0.8-1.0 cm lesions that are not subpleural offers the best opportunity for success. |
3 |
| 126. Arakawa H, Shida H, Saito Y, et al. Pulmonary malignancy in silicosis: factors associated with radiographic detection. Eur J Radiol. 69(1):80-6, 2009 Jan. |
Observational-Dx |
54 patients |
To assess radiographic features of pulmonary malignancies in silicosis and to reveal confounding factors in their detection |
No results stated in the abstract |
2 |
| 127. American College of Radiology. ACR Appropriateness Criteria® Radiation Dose Assessment Introduction. Available at: https://www.acr.org/-/media/ACR/Files/Appropriateness-Criteria/RadiationDoseAssessmentIntro.pdf. |
Review/Other-Dx |
N/A |
To provide evidence-based guidelines on exposure of patients to ionizing radiation. |
No abstract available. |
4 |
